Schneider-Helmert D, Hermann E, Schoenenberger G A
Dtsch Med Wochenschr. 1987 Jun 5;112(23):922-5. doi: 10.1055/s-2008-1068167.
A 47-year old woman patient suffering from chronic delayed sleep phase insomnia and low-dose benzodiazepine dependence was treated as an inpatient under close polygraphic control using DSIP (delta sleep inducing peptide) on an intensive-care basis for one week. This treatment resulted in advancing the main sleep phase by 5 hours, in an abrupt and complete withdrawal of flunitrazepam and restitution of a normal sleep profile. Actographic control during an after treatment week confirmed that the success was maintained.
