维生素D、精液参数及生殖激素与男性不育的关联：一项横断面研究。
The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study.
作者信息
Maghsoumi-Norouzabad Leila, Labibzadeh Maryam, Zare Javid Ahmad, Ahmad Hosseini Seyed, Abbas Kaydani Gholam, Dastoorpur Maryam
机构信息
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Center of Therapy and Research Infertility Jahad Daneshgahi, Ahvaz, Iran.
出版信息
Int J Reprod Biomed. 2022 May 23;20(4):331-338. doi: 10.18502/ijrm.v20i4.10905. eCollection 2022 Apr.
BACKGROUND
The prevalence of vitamin D deficiency and male infertility is high in Iran.
OBJECTIVE
The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men.
MATERIALS AND METHODS
This was a cross-sectional study on 119 infertile men conducted between September 2018 and May 2019. Subjects were divided into 3 groups based on serum vitamin D levels: deficient ( 10 ng/mL), insufficient (10 ng/mL 25(OH)D 30 ng/mL), and sufficient ( 30 ng/mL). Body mass index and waist circumference were measured. 25(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed.
RESULTS
The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p 0.001). Also, in the sufficient group, serum LH (p 0.001) and estradiol (p 0.001, p = 0.01) were notably lower and serum sex hormone-binding globulin (p 0.001) and the testosterone/LH ratio (p 0.001) were considerably higher compared to the insufficient and deficient groups.
CONCLUSION
Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males.
背景
伊朗维生素D缺乏症和男性不育症的患病率很高。
目的
本研究旨在探讨伊朗不育男性血清维生素D[25(OH)D]、精液参数（包括精液量、精子计数、活力和形态）与生殖激素之间的关联。
材料与方法
这是一项于2018年9月至2019年5月对119名不育男性进行的横断面研究。根据血清维生素D水平将受试者分为3组：缺乏组（<10 ng/mL）、不足组（10 ng/mL≤25(OH)D<30 ng/mL）和充足组（≥30 ng/mL）。测量体重指数和腰围。评估25(OH)D、睾酮、性激素结合球蛋白、促黄体生成素（LH）、促卵泡生成素、雌二醇水平以及精液参数。
结果
与其他组相比，充足组的精液量、精子计数、总活动精子和进行性活动精子、正常精子形态、睾酮水平以及睾酮/雌二醇比值显著更高（p<0.001）。此外，与不足组和缺乏组相比，充足组的血清LH（p<0.001）和雌二醇（p<0.001，p = 0.01）显著更低，血清性激素结合球蛋白（p<0.001）和睾酮/LH比值（p<0.001）显著更高。
结论
我们的研究表明，伊朗不育男性的血清维生素D水平与精液参数和性激素之间存在正相关关系。
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