肥胖对伊朗不育男性精液参数及性激素的影响：一项横断面研究
The Impact of Obesity on Various Semen Parameters and Sex Hormones in Iranian Men with Infertility: A Cross-Sectional Study.
作者信息
Maghsoumi-Norouzabad Leila, Zare Javid Ahmad, Aiiashi Saleh, Hosseini Seyed Ahmad, Dadfar Mohammadreza, Bazyar Hadi, Dastoorpur Maryam
机构信息
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Res Rep Urol. 2020 Sep 3;12:357-365. doi: 10.2147/RRU.S258617. eCollection 2020.
OBJECTIVE
The aim of this study was to examine the correlations between body mass index (BMI) and waist circumference (WC) and semen parameters (semen volume, sperm count, motility, and morphology) and sex hormones in Iranian men with infertility.
MATERIALS AND METHODS
In this cross-sectional study, a total of 119 male patients who had lived as a partner in an infertile couple for at least 1 year, after regular unprotected sexual intercourse in their married life were investigated. BMI and WC were assessed, and a morning blood sample was taken assessing serum levels of testosterone (T), sex hormone-binding globulin (SHBG), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and leptin. Semen-analysis parameters were also measured.
RESULTS
Based on BMI and WC, the sperm count, total motility and progressive sperm were significantly lower in overweight and obese infertile males compared to that in normal weight infertile males and those with WC<102 cm. In addition, the fraction of sperm with abnormal morphology was significantly higher in infertile men with WC>102 cm compared to that in those with WC<102 cm. Moreover serum levels of LH, FSH, and leptin were significantly higher in overweight and obese infertile males compared to that in normal weight infertile males and those with WC<102 cm. Moreover serum level of E2 was significantly higher in obese infertile males compared to the normal weight infertile males and in those with WC>102 cm compared to the WC<102 cm. Furthermore, serum level of T was significantly lower in obese infertile males compared to the overweight infertile males and in those with WC>102 cm compared to the WC<102 cm. The mean of T/E2 ratio also was significantly lower in obese infertile males vs overweight and normal weight infertile males and in those with WC>102 cm compared to the WC<102 cm.
CONCLUSION
We concluded that overweight and obesity in infertile men compared to those with normal weight may worsen the infertility situation.
目的
本研究旨在探讨伊朗不育男性的体重指数（BMI）和腰围（WC）与精液参数（精液量、精子计数、活力和形态）以及性激素之间的相关性。
材料与方法
在这项横断面研究中，共调查了119名男性患者，他们在婚后定期无保护性交至少1年后，作为不育夫妇的一方生活。评估了BMI和WC，并采集了早晨血样，检测血清睾酮（T）、性激素结合球蛋白（SHBG）、催乳素（PRL）、黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）和瘦素水平。还测量了精液分析参数。
结果
基于BMI和WC，超重和肥胖不育男性的精子计数、总活力和进行性精子活力显著低于正常体重不育男性和WC<102 cm的男性。此外，WC>102 cm的不育男性中形态异常精子的比例显著高于WC<102 cm的男性。此外，超重和肥胖不育男性的血清LH、FSH和瘦素水平显著高于正常体重不育男性和WC<102 cm的男性。此外，肥胖不育男性的血清E2水平显著高于正常体重不育男性，WC>102 cm的男性血清E2水平显著高于WC<102 cm的男性。此外，肥胖不育男性的血清T水平显著低于超重不育男性，WC>102 cm的男性血清T水平显著低于WC<102 cm的男性。肥胖不育男性的T/E2比值均值也显著低于超重和正常体重不育男性，WC>102 cm的男性T/E2比值均值显著低于WC<102 cm的男性。
结论
我们得出结论，与正常体重的不育男性相比，超重和肥胖可能会使不育情况恶化。
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