Abbasihormozi Sh, Kouhkan A, Alizadeh A R, Shahverdi A H, Nasr-Esfahani M H, Sadighi Gilani M A, Salman Yazdi R, Matinibehzad A, Zolfaghari Z
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Animal Science, Saveh Branch, Islamic Azad University, Saveh, Iran.
Andrology. 2017 Jan;5(1):113-118. doi: 10.1111/andr.12280. Epub 2016 Oct 28.
Although vitamin D deficiency is one of the most common health problems throughout the world, including Iran, conflicting information exists on the potential association between serum vitamin D levels and semen quality. This study intended to evaluate the association between serum vitamin D [25(OH) D3] with semen quality and hormones in Iranian subfertile men. We also compared mean vitamin D and hormone levels in normospermic men with oligoasthenoteratozoospermia (OAT) men. This cross-sectional study was conducted on 278 men who were referred to Royan Infertility Clinic (Tehran, Iran) from March to September 2014. The participants were categorized into two groups; of 186 normospermic and 92 OAT patients according to World Health Organization 2010 criteria. Each participant provided informed consent prior to launching research. Participants completed two general questionnaires of nutritional status. Blood and semen samples were obtained for assessment, and all data were adjusted for age, body mass index (BMI), and season. Vitamin D levels were classified according to Institute of Medicine guidelines. Vitamin D deficiency, insufficiency, and normal levels were observed in 8.6%, 43.6%, 47.8% of participants, respectively. No association was found between daily dietary intake of vitamin D and calcium with sperm parameters. Serum vitamin D was inversely correlated with PTH (p < 0.045). In normospermic men, serum vitamin D levels categorized were not correlated with semen parameters and reproductive hormones (FSH, LH, testosterone(T), and FT), whereas sperm motility showed a positive correlation with vitamin D categorized in OAT men (rs = 0.131, p = 0.028). In conclusion, there was a high incidence of deficiency and insufficiency 25(OH) D Levels (<20ng/ml) observed in Iranian men (52.2%). Moreover, our findings showed a correlation between vitamin D levels and sperm motility in OAT men, which requires further studies.
尽管维生素D缺乏是包括伊朗在内的全球最常见的健康问题之一，但关于血清维生素D水平与精液质量之间的潜在关联，仍存在相互矛盾的信息。本研究旨在评估伊朗不育男性血清维生素D[25(OH)D3]与精液质量及激素之间的关联。我们还比较了正常精子男性与少弱畸精子症（OAT）男性的平均维生素D和激素水平。这项横断面研究于2014年3月至9月对278名转诊至罗扬不孕不育诊所（伊朗德黑兰）的男性进行。根据世界卫生组织2010年标准，参与者被分为两组；186名正常精子者和92名OAT患者。每位参与者在研究开始前均提供了知情同意书。参与者完成了两份营养状况通用问卷。采集血液和精液样本进行评估，并对所有数据进行年龄、体重指数（BMI）和季节校正。维生素D水平根据医学研究所指南进行分类。分别有8.6%、43.6%、47.8%的参与者存在维生素D缺乏、不足和正常水平。未发现维生素D和钙的每日膳食摄入量与精子参数之间存在关联。血清维生素D与甲状旁腺激素呈负相关（p<0.045）。在正常精子男性中，分类的血清维生素D水平与精液参数和生殖激素（促卵泡生成素、促黄体生成素、睾酮（T）和游离睾酮（FT））无关，而在OAT男性中，精子活力与分类的维生素D呈正相关（rs=0.131，p=0.028）。总之，伊朗男性中观察到25(OH)D水平（<20ng/ml）缺乏和不足的发生率较高（52.2%）。此外，我们的研究结果显示OAT男性的维生素D水平与精子活力之间存在相关性，这需要进一步研究。
