儿童原发性肾病综合征的血栓栓塞并发症：突尼斯系列研究。
Thromboembolic complications in children with primary nephrotic syndrome: A Tunisian series.
出版信息
Tunis Med. 2022;100(1):33-36.
INTRODUCTION
Nephrotic syndrome is a common pathology in children. Despite its good prognosis, it can become complicated and threaten the patient's vital and functional prognosis. Thromboembolic complications are rare but serious.
AIM
To study the main thromboembolic events and their outcome during primary nephrotic syndrome in children.
METHODS
It was a retrospective study of the records of children followed for primary nephrotic syndrome who presented one or more thromboembolic events.
RESULTS
Twenty thromboembolic events in 19 children were identified (15 boys and 4 girls). The average age was 5.13±3.4 years at the time of NS diagnosis. The location of the thrombosis was venous in 14 cases. Cerebral venous thrombosis was noted in seven cases, pulmonary thromboembolism in five cases. We noted deep venous thrombosis of lower limbs in three cases, occlusive mesenteric ischemia in two cases, vein portal thrombosis in one case, renal vein thrombosis in one case, and thrombosis of a peripheral artery in one case.
CONCLUSION
Venous and arterial thrombotic complications can occur in children with nephrotic syndrome. Clinical features may be subtle; therefore, neuroimaging and angiographic techniques are essential for diagnosis.
简介
肾病综合征是儿童常见的病理。尽管预后良好，但它可能变得复杂并威胁患者的生命和功能预后。血栓栓塞并发症虽然罕见但很严重。
目的
研究儿童原发性肾病综合征中主要血栓栓塞事件及其结局。
方法
这是一项对接受原发性肾病综合征治疗并出现 1 次或多次血栓栓塞事件的儿童进行回顾性研究。
结果
19 名儿童中发现 20 例血栓栓塞事件（15 名男孩和 4 名女孩）。NS 诊断时的平均年龄为 5.13±3.4 岁。血栓形成部位 14 例为静脉，7 例为脑静脉血栓形成，5 例为肺血栓栓塞。我们注意到 3 例下肢深静脉血栓形成，2 例闭塞性肠系膜缺血，1 例门静脉血栓形成，1 例肾静脉血栓形成，1 例周围动脉血栓形成。
结论
肾病综合征患儿可发生静脉和动脉血栓并发症。临床特征可能不明显；因此，神经影像学和血管造影技术对诊断至关重要。
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