Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.
Jaeb Center for Health Research, Tampa, Florida, USA.
Pediatr Diabetes. 2022 Nov;23(7):1057-1063. doi: 10.1111/pedi.13391. Epub 2022 Jul 23.
Sixty minutes per day of at least moderate to vigorous physical activity (MVPA) is recommended for children for a variety of physical and psychological reasons. Adherence to these guidelines is confounded by challenges with glucose control during exercise in type 1 diabetes (T1D).
This study examined the potential association between physical activity level on active days and glucose control in youth with T1D.
Blinded continuous glucose monitors (CGM: Abbott Libre Pro) and physical activity data as measured from a body monitor patch (Metria IH1) were collected for up to 3 weeks in youth aged 9-17 years with T1D. The association between physical activity levels, expressed as mean active metabolic equivalent minutes (MET-minutes) per day, with CGM-based mean glucose, percent time in range (TIR: 70-180 mg/dl), % time above range (TAR) and % time below range (TBR) were assessed using a linear regression model adjusted for age, gender, and baseline HbA1c.
Study participants were deemed physically active, as defined by at least 10 min of continuous moderate-to-vigorous activity, on 5.2 ± 1.9 days per week, with a median accumulated physical activity time of 61 [IQR: 37-145] minutes per day. Higher physical activity levels were associated with lower mean glucose levels (r = -0.36; p = 0.02) and lower TAR (r = -0.45; p = 0.002) on active days. Higher activity levels were also associated with greater TIR (r = 0.54; p < 0.001) without being associated with more, or less, TBR.
Higher amounts of physical activity are associated with improvements in TIR without significantly increasing TBR. These data suggest that youth ages 9-17 years with T1D can benefit from a high level of physical activity without undue fear of hypoglycemia.
由于各种生理和心理原因，建议儿童每天进行至少 60 分钟的中等到剧烈的身体活动（MVPA）。在 1 型糖尿病（T1D）中，运动期间血糖控制存在挑战，这使得遵循这些指南变得复杂。
本研究旨在探讨 T1D 青少年在活跃日的身体活动水平与血糖控制之间的潜在关联。
在患有 T1D 的 9-17 岁青少年中，使用连续血糖监测仪（Abbott Libre Pro）和身体活动监测贴片（Metria IH1）收集长达 3 周的监测数据。使用线性回归模型评估身体活动水平（以每天平均活跃代谢当量分钟（MET-minutes）表示）与基于 CGM 的平均血糖、TIR（70-180mg/dl）、TAR（%血糖高于范围）和 TBR（%血糖低于范围）之间的关联，该模型调整了年龄、性别和基线 HbA1c。
研究参与者每周被定义为至少有 10 分钟连续中等到剧烈活动，有 5.2±1.9 天，每天平均累积身体活动时间为 61[IQR：37-145]分钟。较高的身体活动水平与活跃日的平均血糖水平较低（r=-0.36；p=0.02）和 TAR 较低（r=-0.45；p=0.002）相关。较高的活动水平也与更高的 TIR（r=0.54；p<0.001）相关，而与 TBR 无关。
较高的身体活动量与 TIR 的改善相关，而不会显著增加 TBR。这些数据表明，9-17 岁患有 T1D 的青少年可以从高水平的身体活动中受益，而不必担心低血糖。
