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[BALB/c小鼠在慢性流感感染及吸入含金属气溶胶情况下肺部肿瘤的发生]

[Development of lung tumors in BALB/c mice in chronic influenza infection and inhalation of metal-containing aerosols].

作者信息

Shevchenko I N, Orlovskiĭ A A, Struk V I

出版信息

Eksp Onkol. 1987;9(2):71-3.

PMID:3582246
Abstract

Intensification of cocarcinogenic effect of chronic influenza infection (10 months after virus instillation) in BALB/c mice was obtained by polymetallic aerosol inhalation 5 or 6 months after infection. An increase of malignant neoplasms incidence was accompanied by a decrease of the cytoproliferative activity in the thymus and spleen. The immunopathogenic and cocarcinogenic effects were maximal when the aerosol treatment was carried out 6 months after infection.

摘要

通过在感染后5或6个月吸入多金属气雾剂,可增强BALB/c小鼠慢性流感感染(病毒接种10个月后)的促癌作用。恶性肿瘤发病率的增加伴随着胸腺和脾脏细胞增殖活性的降低。当在感染后6个月进行气雾剂治疗时,免疫致病和促癌作用最大。

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