Tozzo Pamela
Department of Molecular Medicine, Laboratory of Forensic Genetics, University of Padova, 35121 Padova, Italy.
BioTech (Basel). 2021 Feb 18;10(1):4. doi: 10.3390/biotech10010004.
The preservation of fertility is a clinical issue that has been emerging considerably in recent decades, as the number of patients of childbearing age who risk becoming infertile for many reasons is increasing. The cryopreservation technique of oocytes has been developed for many years and nowadays constitutes a method of safe storage with impressive efficacy and high rates of successful thawing. The storage and use for research of oocytes taken for medical or non-medical can be carried out by both public and private structures, through egg sharing, voluntary egg donation and so-called "social freezing" for autologous use. This paper focuses on the oocyte bank as an emerging cryopreservation facility, in which a collaboration between public and private and the creation of a network of these biobanks can be useful in enhancing both their implementation and their functions. Good oocyte biobank practice would require that they be collected, stored, and used according to appropriate bioethical and bio-law criteria, collected and stored according to procedures that guarantee the best preservation of their structural components and a high level of safety, connected with appropriate procedures to protect the rights and privacy of the parties involved and associated with the results of the bio-molecular investigations that will be carried out gradually.
生育力保存是近几十年来日益凸显的一个临床问题,因为因多种原因面临不孕风险的育龄患者数量在不断增加。卵母细胞冷冻保存技术已经发展多年,如今已成为一种安全的储存方法,具有显著的效果和较高的解冻成功率。医疗或非医疗用途获取的卵母细胞的储存及用于研究,可由公共和私人机构通过卵子共享、自愿卵子捐赠以及所谓的自体使用“社会冷冻”来进行。本文聚焦于作为一种新兴冷冻保存设施的卵母细胞库,其中公私合作以及创建这些生物样本库网络有助于加强其实施和功能。良好的卵母细胞库操作规范要求按照适当的生物伦理和生物法律标准进行采集、储存和使用,按照能确保其结构成分得到最佳保存和高度安全性的程序进行采集和储存,并与保护相关方权利和隐私的适当程序以及将逐步开展的生物分子研究结果相关联。