Wu G, Calamel P M, Shedd D P
Plast Reconstr Surg. 1978 Sep;62(3):396-403. doi: 10.1097/00006534-197809000-00010.
In a study using paired longitudinal flaps on the back of the rat, we found evidence to support the findings of previous investigators regarding the toxic effects of injecting local anesthetic solutions containing epinephrine into delayed flaps. Epinephrine concentrations of 1:200,000 and 1:400,000 were demonstrated to significantly increase losses in these flaps. Epinephrine concentrations of 1:100,000, 1:200,000, and 1:400,000 were not demonstrated to be harmful to undelayed flaps, in the dosages used.
在一项对大鼠背部使用成对纵向皮瓣的研究中，我们发现有证据支持先前研究者关于将含肾上腺素的局部麻醉溶液注入延迟皮瓣的毒性作用的研究结果。已证实1:200,000和1:400,000的肾上腺素浓度会显著增加这些皮瓣的坏死率。在所使用的剂量下，1:100,000、1:200,000和1:400,000的肾上腺素浓度未显示对未延迟皮瓣有害。
