A Real-Time Strategy for Chiroptical Sensing and Enantiomeric Excess Determination of Primary Amines via an Acid-Base Reaction.

作者信息

Wu Datong, Wang Fangqin, Ma Cong, Tan Lilan, Cai Wenrong, Li Junyao, Kong Yong

机构信息

Jiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.

出版信息

Org Lett. 2022 Jul 22;24(28):5226-5229. doi: 10.1021/acs.orglett.2c02246. Epub 2022 Jul 13.

Two achiral aromatic carboxylic acids that included the 1,8-naphthalimide group and an imidazolium cation were synthesized and exploited as chiroptical sensors. These compounds showed the real-time discrimination and enantiomeric excess determination of chiral amines and amino alcohols via an acid-base interaction, especially for UV-silent chiral compounds.