Shelby M D, Cain K T, Cornett C V, Generoso W M
Environ Mutagen. 1987;9(4):363-8. doi: 10.1002/em.2860090403.
Acrylamide (AA), known to induce dominant lethals in male rodents, was studied in the mouse heritable translocation test by using intraperitoneal injections on 5 consecutive days. Matings on days 7-10 following the last injection yielded a high frequency of translocation carriers in the F1 male population, which demonstrated that acrylamide is an effective inducer of translocations in postmeiotic germ cells. As an inducer of both dominant lethals and heritable translocations in late spermatids and early spermatozoa, AA is similar to alkylating agents such as ethylmethanesulfonate and ethylene oxide. However, AA's chemical structure, the nature of adducts formed with DNA, and it lack of mutagenicity in bacteria suggest a different mechanism as the basis for AA's germ cell mutagenicity.
已知丙烯酰胺（AA）可在雄性啮齿动物中诱发显性致死，通过连续5天腹腔注射，在小鼠可遗传易位试验中对其进行了研究。末次注射后第7至10天进行交配，在F1雄性群体中产生了高频率的易位携带者，这表明丙烯酰胺是减数分裂后生殖细胞中易位的有效诱导剂。作为晚期精子细胞和早期精子中显性致死和可遗传易位的诱导剂，AA类似于烷基化剂，如甲基磺酸乙酯和环氧乙烷。然而，AA的化学结构、与DNA形成的加合物的性质以及它在细菌中缺乏诱变性，表明其生殖细胞诱变性的基础机制不同。
