Dobrzyńska M, Lenarczyk M, Gajewski A K
Department of Radiation Protection and Radiobiology, National Institute of Hygiene, Warsaw, Poland.
Mutat Res. 1990 Oct;232(2):209-15. doi: 10.1016/0027-5107(90)90126-o.
The induction of mutations following combined treatment with acrylamide (AA) plus X-rays has been determined using the dominant lethal mutations test in Pzh:SFISS male mice. Combinations of a mutagenic dose of both agents (1.00 Gy, 125 mg/kg b.w.) and a non-mutagenic dose, i.e., a dose that alone does not produce dominant lethals (0.25 Gy, 25 mg/kg b.w.), were used. For the discussion of the effects of combined action of X-rays and acrylamide the term 'enhancement in risk' was used whenever the effects observed after combined exposure significantly exceeded the sum of the effects produced separately by the agents. Such an enhanced risk has been observed in late spermatids after combined action of X-rays and AA at non-mutagenic doses, and in spermatozoa, spermatids and late spermatocytes after exposure to mutagenic doses.
在Pzh:SFISS雄性小鼠中，利用显性致死突变试验测定了丙烯酰胺（AA）与X射线联合处理后诱导的突变情况。使用了两种诱变剂量（1.00 Gy，125 mg/kg体重）和非诱变剂量（即单独使用不会产生显性致死效应的剂量，0.25 Gy，25 mg/kg体重）的组合。为了讨论X射线和丙烯酰胺联合作用的影响，当联合暴露后观察到的效应显著超过各试剂单独产生的效应之和时，使用“风险增强”一词。在非诱变剂量的X射线和AA联合作用后的晚期精子细胞中，以及在暴露于诱变剂量后的精子、精子细胞和晚期精母细胞中，均观察到了这种增强的风险。
