Vistnes L M, Ksander G A, Kosek J
Plast Reconstr Surg. 1978 Oct;62(4):580-8. doi: 10.1097/00006534-197810000-00015.
It has long been known that the formation of a fibrous capsule around an implant is a general phenomenon in nature, an inevitable result of the tissue defense mechanism called the foreign body reaction. We have investigated this reaction in animals and find it consists of a series of interrelated processes in which the final result may vary, depending on the susceptibility of the foreign material to phagocytosis, incorporation by giant cells, or isolation by fibrosis. This susceptibility depends, in turn, on the physical and chemical properties of the implant. The process of capsule formation, as well as the structure of the final capsule, is similar in animal models and in humans--so that investigations of human encapsulation may be done in animals. The cause of abnormal induration around human breast implants is still unknown, and the question of whether normal induration in the animal model can be used to elucidate abnormal clinical induration depends on further investigation of both phenomena.
长期以来，人们一直知道植入物周围形成纤维囊是自然界中的普遍现象，是被称为异物反应的组织防御机制的必然结果。我们已经在动物身上研究了这种反应，发现它由一系列相互关联的过程组成，最终结果可能会有所不同，这取决于异物对吞噬作用、被巨细胞摄取或被纤维化隔离的敏感性。反过来，这种敏感性又取决于植入物的物理和化学性质。在动物模型和人类中，囊形成的过程以及最终囊的结构是相似的——因此对人类包囊化的研究可以在动物身上进行。人类乳房植入物周围异常硬结的原因仍然未知，动物模型中的正常硬结是否可用于阐明异常临床硬结的问题取决于对这两种现象的进一步研究。
