Legrand André P, Marinov Georgi, Pavlov Stoyan, Guidoin Marie-France, Famery Roger, Bresson Bruno, Zhang Ze, Guidoin Robert
Laboratoire de Physique Quantique, ESPCI, 10 rue Vauquelin, 75005, Paris, France.
J Mater Sci Mater Med. 2005 May;16(5):477-85. doi: 10.1007/s10856-005-6989-0.
The formation of a fibrous capsule made of long collagen fibers surrounding breast implants represents an unavoidable phenomenon as the patient's reaction to the presence of a foreign body. Depending upon the size and shape of the implants and the chemicals percolating through the shell, this fibrous capsule is continuously remodeled. The compaction of the foreign debris in the vicinity of the silicone shell is followed by the loss of cellular activity, shrinkage and necrosis. Calcification is the ultimate step. These phenomena were illustrated in the analysis of 18 explanted breast prostheses after 20 or more years of implantation. The degenerative mineralization was shown in scanning electron microscopy and light microscopy. The minerals proved to be bone-like hydroxyapatite by X-ray diffraction and Solid State NMR analysis. Whatever the characteristics of any sophisticated new model of breast implant, phenomenon of mineralization might be minimized but it is very unlikely that it would be totally eliminated.
由围绕乳房植入物的长胶原纤维构成的纤维囊的形成，是患者对异物存在的一种不可避免的反应现象。根据植入物的大小和形状以及透过外壳渗透的化学物质，这种纤维囊会不断重塑。硅酮外壳附近异物碎片的压实之后是细胞活性丧失、萎缩和坏死。钙化是最终阶段。在对18个植入20年或更长时间后取出的乳房假体进行分析时，这些现象得到了证实。扫描电子显微镜和光学显微镜显示了退行性矿化。通过X射线衍射和固态核磁共振分析，证实这些矿物质为类骨羟基磷灰石。无论任何复杂的新型乳房植入物有何特性，矿化现象可能会减至最小，但极不可能被完全消除。
