Berdel D, Süverkrüp R, Heimann G, von Berg A, Liappis N, Stühmer A
Eur J Pediatr. 1987 Jan;146(1):41-3. doi: 10.1007/BF00647281.
Theophylline metabolism and elimination during childhood are age-dependent. The total clearance, which is the sum of metabolic and renal clearances is highest in infants and young children. To differentiate between the two pathways, theophylline concentrations were measured in both serum and urine in 16 children aged 2 weeks-16 years using the fluorescence polarization immunoassay. It was found that both partial clearances assume maximal values at about the same age, but the fraction of total clearance attributable to the renal route decreases continuously.
儿童期茶碱的代谢和消除存在年龄依赖性。总清除率是代谢清除率和肾脏清除率之和，在婴儿和幼儿中最高。为区分这两种途径，采用荧光偏振免疫分析法对16名年龄在2周龄至16岁的儿童的血清和尿液中的茶碱浓度进行了测定。结果发现，两种部分清除率在大约相同的年龄达到最大值，但肾脏途径在总清除率中所占的比例持续下降。
