Bonati M, Latini R, Marra G, Assael B M, Parini R
Pediatr Res. 1981 Apr;15(4 Pt 1):304-8. doi: 10.1203/00006450-198104000-00003.
The metabolic pathway of theophylline (T) was studied in 12 newborns, one young infant, six children, and three adult volunteers. T was injected IV, and blood and urine samples were assayed for T, caffeine (C), and their metabolites by a high-pressure liquid chromatography technique. We confirmed the methylation of T to C in newborn infants but not in older subjects. Demethylation of T to 3-methylxanthine was found in the young infant, in children, and in adults, but not in newborns. The major products excreted by neonates were T, 1-methyluric acid, and 1,3-dimethyluric acid. Children excreted a larger fraction of methyluric acids than adults. Renal and body clearance of T and C are reported and discussed in relation to the age.
在12名新生儿、1名幼儿、6名儿童和3名成年志愿者中研究了茶碱（T）的代谢途径。静脉注射T后，采用高压液相色谱技术对血液和尿液样本中的T、咖啡因（C）及其代谢产物进行检测。我们证实了新生儿中T可甲基化生成C，但在年龄较大的受试者中未发现此现象。在幼儿、儿童和成年人中发现了T脱甲基生成3-甲基黄嘌呤的现象，但新生儿中未发现。新生儿排泄的主要产物是T、1-甲基尿酸和1,3-二甲基尿酸。儿童排泄的甲基尿酸比例高于成年人。报告并讨论了T和C的肾清除率及全身清除率与年龄的关系。
