Albin H, Vinçon G, Begaud B, Bistue C, Perez P
Eur J Clin Pharmacol. 1987;32(1):97-9. doi: 10.1007/BF00609966.
The effect of aluminum phosphate on the bioavailability of ranitidine has been investigated in 10 young, healthy volunteers. Following a random cross over design, each subject took at a 1 week interval 150 mg ranitidine alone or with 11 g aluminum phosphate. Plasma and urine ranitidine levels were measured by HPLC. The antacid reduced both the maximum plasma ranitidine concentration by 40% and the area under the curve by 30%. Elimination of ranitidine was not changed. The results indicate that aluminum phosphate significantly diminished the bioavailability of ranitidine.
已在10名年轻健康志愿者中研究了磷酸铝对雷尼替丁生物利用度的影响。按照随机交叉设计，每位受试者每隔1周服用150毫克雷尼替丁，单独服用或与11克磷酸铝一起服用。通过高效液相色谱法测定血浆和尿液中的雷尼替丁水平。抗酸剂使血浆雷尼替丁最大浓度降低了40%，曲线下面积降低了30%。雷尼替丁的消除未发生变化。结果表明，磷酸铝显著降低了雷尼替丁的生物利用度。
