酮替芬与茶碱在哮喘儿童中的非相互作用——一项急性研究。
Non-interaction of ketotifen and theophylline in children with asthma--an acute study.
作者信息
Garty M, Scolnik D, Danziger Y, Volovitz B, Ilfeld D N, Varsano I
出版信息
Eur J Clin Pharmacol. 1987;32(2):187-9. doi: 10.1007/BF00542193.
PMID:3582483
Abstract
Six asthmatic children participated in an acute crossover randomized study. They received a single dose of aminophylline syrup 6 mg/kg after having received ketotifen syrup 1 mg b.i.d. or placebo for 8 days. Ketotifen did not significantly affect the heart rate, pulse pressure or such pharmacokinetic parameters of theophylline as peak serum level, time to peak, half life and AUC. Thus, ketotifen had no significant effect on the disposition of theophylline.
摘要
六名哮喘儿童参与了一项急性交叉随机研究。他们在接受了8天每日两次1毫克酮替芬糖浆或安慰剂治疗后，接受了单次剂量6毫克/千克的氨茶碱糖浆。酮替芬对心率、脉压或茶碱的药代动力学参数（如血清峰值水平、达峰时间、半衰期和曲线下面积）没有显著影响。因此，酮替芬对茶碱的处置没有显著影响。
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