Pragay E B, Mirsky A F, Nakamura R K
Exp Neurol. 1987 Jun;96(3):481-500. doi: 10.1016/0014-4886(87)90213-5.
Unit activity related to a go/no-go visual discrimination task was studied in four rhesus monkeys. We recorded 272 task-related cells from frontal cortex in a region extending from the midprincipal sulcus to the central sulcus, and medially to the cingulate sulcus. Units located in anterior regions (dorsolateral prefrontal and anterior cingulate cortex) were typically related to both go and no-go trials (designated type II units) and showed similar ("symmetrical") activity in both kinds of trials; some of them also showed prestimulus ("anticipatory") activity. Such units were present but less common in posterior regions (postarcuate and precentral and posterior cingulate cortex). Units in these posterior regions were active predominantly in go trials (designated type I units). Also found posteriorly were "asymmetrical" type II cells whose activity was greater in go trials and occurred later in the trial, around the behavioral response. The anterior symmetrical and anticipatory type II units in the frontal association cortex were similar to such units described earlier in the brain stem reticular formation and may have similar functions in supporting focused and preparatory attention. On the other hand, asymmetrical type II units in the posterior frontal regions may have a role in the initiation of visually guided motor behavior.
我们在四只恒河猴身上研究了与视觉辨别“是/否”任务相关的单位活动。我们从额叶皮层中一个从中央沟延伸至中央沟、内侧至扣带沟的区域记录了272个与任务相关的细胞。位于前部区域（背外侧前额叶和前扣带皮层）的单位通常与“是”和“否”试验都有关（称为II型单位），并且在两种试验中表现出相似的（“对称”）活动；其中一些还表现出刺激前（“预期”）活动。这些单位在后部区域（弓形后、中央前和后扣带皮层）也存在，但较少见。这些后部区域的单位主要在“是”试验中活跃（称为I型单位）。在后部还发现了“不对称”的II型细胞，其活动在“是”试验中更强，且在试验后期出现，大约在行为反应时。额叶联合皮层中的前部对称和预期II型单位类似于先前在脑干网状结构中描述的此类单位，并且在支持集中和预备性注意力方面可能具有相似的功能。另一方面，后部额叶区域中的不对称II型单位可能在视觉引导的运动行为启动中起作用。
