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[应对皮质醇时自我刺激之间停顿持续时间的变化]

[Changes in the duration of pauses between self-stimulations in response to cortisol].

作者信息

Belyĭ V P

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1987 Mar;73(3):347-52.

PMID:3582695
Abstract

Intraperitoneal administration of glucocorticoid hormone cortisol (10 mg/kg) decelerated the self-stimulation (SS) frequency within 5-7 min. The maximal effect occurred within 10 to 20 min. Histograms of pauses duration between SS revealed a shift of mean values from 2.0-2.5 to 4-6 sec. A sharp increase of long pauses transformed chiefly mono- modal forms of control histograms into bimodal those under the hormonal effect. Behaviourally this was manifested by occurrence of burst type of SS responses when series of uninterrupted instrumental responses alternated with prolonged pauses between them. The data obtained are considered from the stand-point of systemic approach to analysis of organization of willed behaviour and role of cortisol in central mechanisms of positive reinforcement.

摘要

腹腔注射糖皮质激素皮质醇(10毫克/千克)可在5 - 7分钟内使自我刺激(SS)频率减慢。最大效应出现在10至20分钟内。SS之间暂停持续时间的直方图显示平均值从2.0 - 2.5秒移至4 - 6秒。长时间暂停的急剧增加主要将对照直方图的单峰形式转变为激素作用下的双峰形式。行为上,这表现为SS反应出现爆发类型,即一系列不间断的工具性反应之间交替出现长时间暂停。从系统方法的角度来考虑所获得的数据,该方法用于分析意志行为的组织以及皮质醇在正强化中枢机制中的作用。

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