雄性大鼠肾上腺素能和非肾上腺素能外周神经元中脂色素与年龄相关的积累差异。

Difference in the age-related accumulation of lipopigments in the adrenergic and nonadrenergic peripheral neurons in the male rat.

作者信息

Koistinaho J

出版信息

Gerontology. 1986;32(6):300-7. doi: 10.1159/000212808.

Abstract

The age-related accumulation of lipopigments was determined in the adrenergic and nonadrenergic peripheral neurons of the rat using a microspectrofluorometric method and electron microscopy, 3-, 12- and 30-month-old rats were used. The rate of lipopigment accumulation was greater in nonadrenergic than adrenergic neurons. The nonadrenergic neurons showed an emission maximum at 500 nm, while the emission maximum of adrenergic neurons was at 515-520 nm. Electron microscopy revealed a neuromelanin-like component in the pigment bodies of adrenergic neurons but not in nonadrenergic neurons. The results indicate that age-related lipopigment accumulation has a differential and selective pattern also in the peripheral nervous system.

摘要

采用显微分光荧光测定法和电子显微镜技术，对3个月、12个月和30个月大的大鼠的肾上腺素能和非肾上腺素能外周神经元中与年龄相关的脂褐素积累情况进行了测定。非肾上腺素能神经元中脂褐素的积累速率高于肾上腺素能神经元。非肾上腺素能神经元在500nm处有最大发射峰，而肾上腺素能神经元的最大发射峰在515 - 520nm处。电子显微镜检查发现，肾上腺素能神经元的色素体中有类似神经黑素的成分，而非肾上腺素能神经元中则没有。结果表明，在周围神经系统中，与年龄相关的脂褐素积累也具有差异和选择性模式。