人类交感神经节中脂色素的年龄相关性异质性。

Age related heterogeneity of lipopigments in human sympathetic ganglia.

作者信息

Hervonen A, Koistinaho J, Alho H, Helen P, Santer R M, Rapoport S I

出版信息

Mech Ageing Dev. 1986 Jun;35(1):17-29. doi: 10.1016/0047-6374(86)90062-x.

Abstract

The histochemical, autofluorescence and morphological characteristics of lipopigments accumulating with age in the human sympathetic neurons were studied. The spectral characteristics of the lipopigment autofluorescence change with age suggesting the accumulation of additional components in the residual bodies. This component is electron microscopically highly osmiophilic and stains also with silver staining. These changes may indicate the gradual melanization of the lipopigments due to auto-oxidation of catecholamines. The accumulation of the melanized form of lipopigment may be a sign of more advanced cellular trauma.

摘要

对人类交感神经元中随年龄积累的脂褐素的组织化学、自发荧光和形态学特征进行了研究。脂褐素自发荧光的光谱特征随年龄变化，表明残余小体中积累了额外的成分。该成分在电子显微镜下具有高度嗜锇性，也能用银染法染色。这些变化可能表明由于儿茶酚胺的自动氧化，脂褐素逐渐发生黑素化。脂褐素黑素化形式的积累可能是更严重细胞损伤的一个迹象。