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糖皮质激素对血液系统恶性肿瘤患者（无已知糖尿病诊断）间质葡萄糖浓度的影响：一项初步研究。

Effects of glucocorticoids on interstitial glucose concentrations in individuals with hematologic cancer and without known diagnosis of diabetes: a pilot study.

机构信息

Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

出版信息

Einstein (Sao Paulo). 2022 Jul 8;20:eAO8031. doi: 10.31744/einstein_journal/2022AO8031. eCollection 2022.

DOI:10.31744/einstein_journal/2022AO8031
PMID:35830152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9262279/
Abstract

OBJECTIVE

To analyze interstitial glucose behavior during glucocorticoid use in non-diabetic patients receiving chemotherapy for hematologic malignancies.

METHODS

Prospective pilot study carried out to assess interstitial glucose levels in 15 non-diabetic individuals with hematologic malignancies who received glucocorticoids in combination with chemotherapy. The FreeStyle Libre flash monitoring system (Abbott Diabetes Care) was used for up to 14 days to measure interstitial glucose.

RESULTS

Median age and body mass index were 53 (42-61) years and 25 (23-28) kg/m2 respectively. Interstitial glucose levels >180mg/dL lasting at least one hour were detected in 60% of participants. Interstitial glucose profile parameters (median and peak interstitial glucose levels and percentage of time during which interstitial glucose levels were >180mg/dL) were significantly (p<0.01) higher during glucocorticoid use (115mg/dL, 218mg/dL and 10% respectively) than after glucocorticoid discontinuation (97mg/dL, 137mg/dL and 0% respectively). Mean interstitial glucose levels increased in the afternoon and at night during glucocorticoid use.

CONCLUSION

This pilot study was the first to evaluate interstitial glucose levels in non-diabetic individuals using glucocorticoids in treatment of hematologic cancer. Glucocorticoid use during chemotherapy significantly increases interstitial glucose levels in these patients.

摘要

目的

分析非糖尿病血液病化疗患者使用糖皮质激素时的间质葡萄糖行为。

方法

进行前瞻性试点研究，评估 15 例接受糖皮质激素联合化疗的非糖尿病血液病患者的间质葡萄糖水平。使用 FreeStyle Libre 闪光监测系统（雅培糖尿病护理）测量间质葡萄糖长达 14 天。

结果

中位年龄和体重指数分别为 53（42-61）岁和 25（23-28）kg/m2。60%的参与者检测到间质葡萄糖水平>180mg/dL 持续至少 1 小时。糖皮质激素使用期间（115mg/dL、218mg/dL 和 10%）间质葡萄糖谱参数（中位和峰值间质葡萄糖水平以及>180mg/dL 的时间百分比）显著高于糖皮质激素停药后（97mg/dL、137mg/dL 和 0%）（p<0.01）。糖皮质激素使用期间，下午和夜间的平均间质葡萄糖水平升高。

结论

本试点研究首次评估了糖皮质激素治疗血液病患者的非糖尿病患者的间质葡萄糖水平。化疗期间使用糖皮质激素会显著增加这些患者的间质葡萄糖水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/713f/9262279/e22fc1bd640b/2317-6385-eins-20-eAO8031-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/713f/9262279/999a8472fe52/2317-6385-eins-20-eAO8031-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/713f/9262279/e22fc1bd640b/2317-6385-eins-20-eAO8031-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/713f/9262279/999a8472fe52/2317-6385-eins-20-eAO8031-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/713f/9262279/e22fc1bd640b/2317-6385-eins-20-eAO8031-gf02.jpg

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