监管应用中烟草产品的体外测试的关键挑战：推荐剂量学。
Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry.
机构信息
Scientific & Regulatory Affairs, JT International SA, Geneva, Switzerland.
Institute for In Vitro Sciences, Gaithersburg, Maryland, USA.
出版信息
Drug Test Anal. 2023 Oct;15(10):1175-1188. doi: 10.1002/dta.3344. Epub 2022 Aug 16.
Abstract
The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across tobacco and various next-generation products (NGPs) including heated tobacco products (HTPs) and electronic nicotine delivery systems (ENDSs). This publication was developed by a working group of the workshop members in conjunction with the sixth workshop in that series entitled "Dosimetry for conducting in vitro evaluations" and focuses on aerosol dosimetry for aerosol exposure to combustible cigarettes, HTP, and ENDS aerosolized tobacco products and summarizes the key challenges as well as documenting areas for future research.
摘要
体外科学研究所（IIVS）正在主办一系列研讨会，旨在制定最佳科学和技术方法的建议，以进行体外检测，评估烟草和各种新一代产品（NGP）内和跨产品的潜在毒性，包括加热烟草产品（HTP）和电子尼古丁传送系统（ENDS）。本出版物是由该研讨会成员的一个工作组与该系列的第六次研讨会“进行体外评估的计量学”共同制定的，重点介绍了对可燃香烟、HTP 和 ENDS 气溶胶化烟草产品进行气溶胶暴露的气溶胶计量学，并总结了主要挑战，并记录了未来研究的领域。
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