University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Department of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, 30-387 Kraków, Poland.
Org Lett. 2022 Jul 22;24(28):5014-5017. doi: 10.1021/acs.orglett.2c01642. Epub 2022 Jul 13.
A short, concise, and one-pot synthesis of imidazo-fused heterocycle dimers with tunable fluorescent properties has been developed. By the first time use of glyoxal dimethyl acetal in the Groebke-Blackburn-Bienaymé (GBB) three-component reaction (3CR), the innovation features a new series of fluorescence-tunable imidazo-fused heterocycle dimers exhibiting a broad substrate scope with good yields. Luminescence studies demonstrate that these GBB-dimers possess color-tunable properties, and their emission colors can be successively changed from blue to green and yellow by easy substituent control.
一种简短、简洁且一锅合成的具有可调谐荧光性质的咪唑稠合杂环二聚体已被开发出来。通过首次在 Groebke-Blackburn-Bienaymé (GBB) 三组分反应 (3CR) 中使用乙二醛二甲缩醛，该创新具有一系列新的荧光可调谐咪唑稠合杂环二聚体，具有广泛的底物范围和良好的产率。发光研究表明，这些 GBB-二聚体具有可调节颜色的性质，并且可以通过简单的取代基控制，将其发射颜色从蓝色连续变为绿色和黄色。
