在各种硅酸钙基骨水泥中培养的SHEDS的生物相容性、生物活性和基因表达分析：体外研究的系统评价和荟萃分析
Biocompatibility, Bioactivity and Gene Expression Analysis of SHEDS Cultured in Various Calcium Silicate Based Cements: A Systematic Review and Meta-Analysis of in Vitro Studies.
作者信息
Maru Viral, Dixit Uma, Shetty Ashveeta
机构信息
From the Department of Perodontics and Preventative Dentistry, D Y School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.
Viral Maru, MDS, MBA, PhD Student.
出版信息
J Clin Pediatr Dent. 2022 May 1;46(3):171-182. doi: 10.17796/1053-4625-46.3.1.
AIM
To assess the biocompatibility, bioactivity and gene expression analysis of SHEDs incubated in various Calcium Silicate Based Cements.
STUDY DESIGN
Following PRISMA statement, a search was carried out in the electronic databases-PubMed, Scopus, Embase, Google Scholar, JSTOR, and DOAJ from January 2000 to 31 May 2021. In vitro trials examining the response of SHEDs to the treatment with CSCs were eligible.
RESULTS
10 trials were included after the selection process. These trials involved the assessment of cell viability, cell migration, cell adhesion, mineralization potential and gene expression analysis of SHEDs cultured in MTA, Biodentine, EndoCem Zr, RetroMTA, TheraCal & iRoot BP plus.
CONCLUSION
MTA, Biodentine, EndoCem Zr, RetroMTA and iRoot BP showed adequate biocompatibility, bioactivity and genetic expression towards SHEDs, to support their clinical use in vital pulp treatment of primary teeth.
目的
评估在各种硅酸钙基水门汀中培养的乳牙干细胞（SHEDs）的生物相容性、生物活性及基因表达分析。
研究设计
遵循PRISMA声明，于2000年1月至2021年5月31日在电子数据库——PubMed、Scopus、Embase、谷歌学术、JSTOR和DOAJ中进行检索。纳入检测SHEDs对硅酸钙基水门汀（CSCs）处理反应的体外试验。
结果
筛选过程后纳入10项试验。这些试验涉及评估在MTA、生物活性齿科修复材料（Biodentine）、EndoCem Zr、RetroMTA、TheraCal和iRoot BP plus中培养的SHEDs的细胞活力、细胞迁移、细胞黏附、矿化潜能及基因表达分析。
结论
MTA、Biodentine、EndoCem Zr、RetroMTA和iRoot BP对SHEDs显示出足够的生物相容性、生物活性及基因表达水平，以支持它们在乳牙活髓治疗中的临床应用。
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