通过蝶酰三谷氨酸去共轭生成叶酸来评估进行性系统性硬化症中的肠上皮细胞功能。
Enterocyte function in progressive systemic sclerosis as estimated by the deconjugation of pteroyltriglutamate to folic acid.
作者信息
Hendel L, Hendel J, Joergensen I
出版信息
Gut. 1987 Apr;28(4):435-8. doi: 10.1136/gut.28.4.435.
As a measure of enterocyte function, the deconjugation of pteroyl-L-glutamyl-gamma-L-glutamyl-gamma-L-glutamic acid to folic acid and subsequent active absorption was measured in 19 patients with progressive systemic sclerosis and compared with 14 controls. The absorption step of folic acid was identical in the two groups, while deconjugation of pteroyl-L-glutamyl-gamma-L-glutamyl-gamma-L-glutamic acid was significantly decreased in the patients with progressive systemic sclerosis. This observation suggests a primary epithelial defect of the small intestine in patients with progressive systemic sclerosis.
作为肠上皮细胞功能的一项指标，对19例进行性系统性硬化症患者测定了蝶酰-L-谷氨酰-γ-L-谷氨酰-γ-L-谷氨酸脱共轭生成叶酸及随后的主动吸收情况，并与14名对照者进行了比较。两组中叶酸的吸收步骤相同，而进行性系统性硬化症患者中蝶酰-L-谷氨酰-γ-L-谷氨酰-γ-L-谷氨酸的脱共轭作用显著降低。这一观察结果提示进行性系统性硬化症患者存在小肠原发性上皮缺陷。
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