妊娠毒血症中胎盘蛋白（PP5和PP10）的血清浓度与宫内生长迟缓的关系。

Serum concentration of placental proteins (PP5 and PP10) in toxemia of pregnancy as related to intrauterine growth retardation.

作者信息

Takayama M, Soma H, Isaka K, Okudera K, Ogawa T, Ueda A

出版信息

Gynecol Obstet Invest. 1987;23(2):89-96. doi: 10.1159/000298841.

Abstract

Maternal serum concentrations of placental proteins 5 (PP5) and 10 (PP10) were measured by radioimmunoassay in 568 samples obtained from 308 healthy pregnant women and 63 women having toxemia of pregnancy. Below-normal PP5 values were more widely distributed in the mild than in the severe toxemia group, while the incidence of above-normal PP5 values was found only in the severe toxemia group. The incidence of below-normal PP10 values was higher in the severe than in the mild toxemia group. Our study thus suggests that simultaneous measurement of PP5 and PP10 concentrations in maternal serum in toxemia of pregnancy is a useful monitoring technique for predicting progressive pathological change and placental dysfunction related to IUGR.

摘要

采用放射免疫分析法测定了308名健康孕妇和63名妊娠中毒症妇女的568份样本中的母体血清胎盘蛋白5（PP5）和胎盘蛋白10（PP10）浓度。轻度妊娠中毒症组中PP5值低于正常范围的分布比重度组更广泛，而PP5值高于正常范围的情况仅在重度妊娠中毒症组中出现。重度妊娠中毒症组中PP10值低于正常范围的发生率高于轻度组。因此，我们的研究表明，同时测定妊娠中毒症孕妇母体血清中PP5和PP10的浓度是预测与宫内生长受限相关的进行性病理变化和胎盘功能障碍的一种有用的监测技术。