Imaizumi H
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Feb;35(2):159-67.
Pregnant serum PAPP-A, SP1 and HPL concentration were measured in 188 normal pregnant sera, 43 pathological sera by Laurell's method for PAPP-A and HPL, by SRID method for SP1. PAPP-A was detected from about 10 weeks of gestational age. Throughout the pregnancy, PAPP-A concentration correlated to gestational age significantly (r = 0.773), while the correlation was not observed in late pregnancy. In normal pregnancy, PAPP-A concentration correlated to both SP1 and HPL concentration through all gestational age significantly. In abnormal pregnancy, however, PAPP-A concentration increased in severe toxemia and IUGR against decreasing SP1 and HPL concentrations. So far as twin pregnancy and hydramnion, PAPP-A, SP1 and HPL concentrations increased together. These results indicate that PAPP-A concentration may reflect feto-placental function in normal pregnancy and predict some obstetric disorders.
采用劳雷尔法检测188例正常孕妇血清及43例病理孕妇血清中的妊娠相关血浆蛋白-A（PAPP-A）、妊娠特异性β1糖蛋白（SP1）和人胎盘催乳素（HPL）浓度，其中PAPP-A和HPL采用劳雷尔法，SP1采用单向免疫扩散法（SRID）。妊娠约10周时可检测到PAPP-A。整个孕期，PAPP-A浓度与孕周显著相关（r = 0.773），但孕晚期未观察到这种相关性。在正常妊娠中，PAPP-A浓度在整个孕周均与SP1和HPL浓度显著相关。然而，在异常妊娠中，重度子痫前期和胎儿宫内生长受限（IUGR）时PAPP-A浓度升高，而SP1和HPL浓度降低。就双胎妊娠和羊水过多而言，PAPP-A、SP1和HPL浓度同时升高。这些结果表明，PAPP-A浓度可能反映正常妊娠时的胎儿-胎盘功能，并预测一些产科疾病。
