Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Langone Health, New York, NY.
Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Langone Health, New York, NY.
J Cardiothorac Vasc Anesth. 2022 Oct;36(10):3867-3876. doi: 10.1053/j.jvca.2022.05.025. Epub 2022 May 23.
Heart failure affects 6.2 million adults in the United States (US), resulting in a decrease in quality of life. Limited options exist for the treatment of end-stage heart failure. Mechanical circulatory support and transplantation are considered when no further optimization can be obtained with medical management. Heart transplant is regarded as superior to mechanical assist devices due to a lower incidence of multiorgan dysfunction. However, transplants are limited by the availability of donor organs. Heart transplants using organs from donation after circulatory death (DCD) have blossomed globally since 2014; whereas, in the US, this method has had a slower implementation. Today, the realization of the need to increase the number of donor hearts has reinvigorated the interest in heart transplantation using DCD organs. The authors review the process and discuss the unique opportunities anesthesiologists have to impact the future success of DCD heart transplantation as it continues to expand.
心力衰竭影响了美国 620 万成年人,导致生活质量下降。对于终末期心力衰竭的治疗选择有限。当无法通过药物治疗进一步优化时,会考虑使用机械循环支持和移植。由于机械辅助设备发生多器官功能障碍的几率较低,心脏移植被认为优于机械辅助设备。然而,由于供体器官的缺乏,心脏移植受到限制。自 2014 年以来,全球范围内使用循环死亡后捐献(DCD)器官的心脏移植蓬勃发展;而在美国,这种方法的实施速度较慢。如今,人们认识到需要增加供心数量,这重新激发了人们对使用 DCD 器官进行心脏移植的兴趣。作者回顾了这一过程,并讨论了麻醉医生在继续扩大 DCD 心脏移植的未来成功方面所具有的独特机会。