Experimental chemotherapy of Angiostrongylus cantonensis infection in mice with flubendazole, levamisole, and their combination.

The efficacy of the drugs flubendazole, levamisole, and their combination was studied against Angiostrongylus cantonensis infection in mice. The drugs were evaluated on day 15 post infection. The efficacy was assessed by using single-dose and 5-dose treatment schedules. Flubendazole was effective at 25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg when given each day for five days. Levamisole at a dose rate of 200 mg/kg was completely effective in a single treatment. The combined therapy of levamisole (25 mg/kg) and flubendazole (15 mg/kg) produced 100% efficacy. Both drugs given prior to experimental infection showed no prophylactic activity.