曲昔派特对大鼠急性胃黏膜损伤的影响

[Effects of troxipide on acute gastric lesions in rats].

作者信息

Sekiguchi H, Hamada K, Okada Y, Taga F

出版信息

Nihon Yakurigaku Zasshi. 1987 Mar;89(3):111-9. doi: 10.1254/fpj.89.111.

DOI:10.1254/fpj.89.111

Abstract

Effects of troxipide on several acute gastric lesions in rats were investigated in comparison with those of cetraxate. Troxipide (100, 200, 300 mg/kg) and cetraxate (100, 300, 1,000 mg/kg), given orally, dose-dependently protected the gastric mucosa from damage due to ethanol. Aspirin- and 0.6 N HCl-induced gastric lesions were dose-dependently inhibited by troxipide (200, 300 mg/kg), but only significantly inhibited by cetraxate at high dose (1,000 mg/kg). Troxipide (100, 200, 300 mg/kg) dose-dependently prevented the formation of gastric lesions induced by water-immersion stress, whereas cetraxate (600, 1,000 mg/kg) also significantly prevented gastric lesions. That is, protective effects of troxipide were much more potent than those of cetraxate against aspirin-, 0.6 N HCl- and water-immersion stress-induced gastric lesions, whereas both were almost equal against ethanol-induced gastric lesions. In addition, cytoprotective effects of troxipide against ethanol-induced lesions were most remarkable at 10, 30, 60 min after administration (100, 300 mg/kg) and lasted for up to 240 min. These results suggested that troxipide might be useful for the treatment of acute gastric lesions in humans.

摘要

与西曲酸酯相比，研究了曲昔匹特对大鼠几种急性胃损伤的影响。口服曲昔匹特（100、200、300mg/kg）和西曲酸酯（100、300、1000mg/kg）可剂量依赖性地保护胃黏膜免受乙醇损伤。曲昔匹特（200、300mg/kg）可剂量依赖性地抑制阿司匹林和0.6N盐酸诱导的胃损伤，但西曲酸酯仅在高剂量（1000mg/kg）时具有显著抑制作用。曲昔匹特（100、200、300mg/kg）可剂量依赖性地预防水浸应激诱导的胃损伤形成，而西曲酸酯（600、1000mg/kg）也可显著预防胃损伤。也就是说，曲昔匹特对阿司匹林、0.6N盐酸和水浸应激诱导的胃损伤的保护作用比西曲酸酯更强，而两者对乙醇诱导的胃损伤的保护作用几乎相同。此外，曲昔匹特对乙醇诱导损伤的细胞保护作用在给药后10、30、60分钟（100、300mg/kg）最为显著，持续长达240分钟。这些结果表明，曲昔匹特可能对治疗人类急性胃损伤有用。