Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy and Physiotherapy, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Solna, Stockholm, Sweden.
Acta Neurochir (Wien). 2022 Sep;164(9):2367-2373. doi: 10.1007/s00701-022-05309-4. Epub 2022 Jul 13.
Normal pressure hydrocephalus (NPH) is a neurological disorder, characterized by gait- and balance disturbance, cognitive deterioration, and urinary incontinence, combined with ventricular enlargement. Gait ability, falls, cognitive status, and health-related quality of life pre and post surgery have not previously been studied at Karolinska University Hospital.
One hundred and eighteen patients with iNPH that underwent shunt surgery at Karolinska University Hospital during the years from 2016 to 2018 were included. Results of walking tests, test for cognitive function, and self-estimated health-related quality of life, before and 3 months after surgery, were collected retrospectively as a single-center study.
Walking ability, cognitive function, and health-related quality of life significantly increased 3 months after shunt surgery. A positive significant correlation was seen between a higher self-estimated quality of life and walking ability.
Patients with suspected iNPH treated with shunt surgery at Karolinska University Hospital improved their walking ability and cognitive functioning 3 months after shunt surgery. A positive significant correlation was seen between a higher self-estimated quality of life and walking ability but not with increased cognitive function. We then concluded that the selection of patients for shunting maintained a high standard.
常压性脑积水（NPH）是一种神经系统疾病，其特征是步态和平衡障碍、认知能力下降和尿失禁，同时伴有脑室扩大。步态能力、跌倒、认知状态和手术前后的健康相关生活质量在此前并未在卡罗林斯卡大学医院进行过研究。
纳入了 2016 年至 2018 年期间在卡罗林斯卡大学医院接受分流手术的 118 例 iNPH 患者。作为一项单中心研究，回顾性收集了手术前后行走测试、认知功能测试和自我估计的健康相关生活质量的结果。
分流手术后 3 个月，患者的行走能力、认知功能和健康相关生活质量显著提高。自我估计的生活质量越高，与行走能力呈正相关。
在卡罗林斯卡大学医院接受分流手术治疗的疑似 iNPH 患者，在分流手术后 3 个月时，其行走能力和认知功能得到改善。自我估计的生活质量越高，与行走能力呈正相关，但与认知功能的提高无关。因此，我们得出结论，分流手术患者的选择标准保持较高。
