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麻风病:流行病学、临床诊断与管理综述

Leprosy: A Review of Epidemiology, Clinical Diagnosis, and Management.

作者信息

Chen Kou-Huang, Lin Cheng-Yao, Su Shih-Bin, Chen Kow-Tong

机构信息

School of Mechanical and Electronic Engineering, Sanming University, Sanming, Fujian, China.

Division of Hematology-Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.

出版信息

J Trop Med. 2022 Jul 4;2022:8652062. doi: 10.1155/2022/8652062. eCollection 2022.

DOI:10.1155/2022/8652062
PMID:35832335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9273393/
Abstract

Leprosy is a neglected infectious disease caused by acid-fast bacillus . It primarily affects the skin and then progresses to a secondary stage, causing peripheral neuropathy with potential long-term disability along with stigma. Leprosy patients account for a significant proportion of the global disease burden. Previous efforts to improve diagnostic and therapeutic techniques have focused on leprosy in adults, whereas childhood leprosy has been relatively neglected. This review aims to update the diagnostic and therapeutic recommendations for adult and childhood leprosy. This review summarizes the clinical, bacteriological, and immunological approaches used in the diagnosis of leprosy. As strategies for the diagnosis and management of leprosy continue to develop better and more advanced knowledge, control and prevention of leprosy are crucial.

摘要

麻风病是一种由抗酸杆菌引起的被忽视的传染病。它主要影响皮肤,随后发展到第二阶段,导致周围神经病变,并可能造成长期残疾以及带来污名化。麻风病患者在全球疾病负担中占相当大的比例。以往改善诊断和治疗技术的努力主要集中在成人麻风病上,而儿童麻风病相对受到忽视。本综述旨在更新成人和儿童麻风病的诊断和治疗建议。本综述总结了用于麻风病诊断的临床、细菌学和免疫学方法。随着麻风病诊断和管理策略不断发展出更好、更先进的知识,麻风病的控制和预防至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/b66a5538782e/JTM2022-8652062.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/86e931e2c0ba/JTM2022-8652062.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/5fb8ccb5e088/JTM2022-8652062.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/578a789fc86d/JTM2022-8652062.004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/b66a5538782e/JTM2022-8652062.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/86e931e2c0ba/JTM2022-8652062.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/1b1f4f6f5f9e/JTM2022-8652062.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/5fb8ccb5e088/JTM2022-8652062.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/578a789fc86d/JTM2022-8652062.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/b6eec3e132f7/JTM2022-8652062.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935f/9273393/b66a5538782e/JTM2022-8652062.006.jpg

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Am J Trop Med Hyg. 2022 Jan 10;106(3):775-778. doi: 10.4269/ajtmh.21-0458.
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Epidemiological characteristics and trends of leprosy in children and adolescents under 15 years old in a low-endemic State in Southern Brazil.巴西南部低流行州 15 岁以下儿童和青少年麻风病的流行病学特征和趋势。
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The multiple roles of the NlpC_P60 peptidase family in mycobacteria - an underexplored target for antimicrobial drug discovery.NlpC_P60肽酶家族在分枝杆菌中的多重作用——抗菌药物发现的一个未被充分探索的靶点
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An Infectious Disease Mimicking Rheumatologic Disease in an Adolescent.一名青少年中类似风湿性疾病的感染性疾病
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