中国南方11个少数民族群体中的转铁蛋白亚型

Transferrin subtypes in 11 south China minority populations.

作者信息

Chen J X, Chen Q, Xu J J, Du R F

机构信息

Laboratory of Blood Typing and Serology, Chinese Academy of Medical Sciences, Chengdu.

出版信息

Hum Hered. 1992;42(2):111-9. doi: 10.1159/000154050.

DOI:10.1159/000154050

PMID:1572669

Abstract

Transferrin subtypes were determined by isoelectric focussing (IEF) in a total of 2,121 individuals from 11 South China minority populations. The C1, C2 and DCHI alleles were present in all the populations; B alleles were lacking, C4 was found in 3 populations and C3 in 6. C2 and C4 allele frequencies are notable in these minority groups. The frequency of the C2 allele was higher (0.25-0.38) than that of Han Chinese (0.18-0.25). In Bai the C2 frequency was as high as 0.38. The C4 allele was present at a low frequency (less than 0.01), which suggests that this allele probably existed in the ancestral Mongoloid population at a low frequency and increased in frequency in Amerindians due to genetic drift or other factors.

摘要

通过等电聚焦（IEF）对来自中国南方11个少数民族群体的2121名个体进行了转铁蛋白亚型测定。所有群体中均存在C1、C2和DCHI等位基因；不存在B等位基因，在3个群体中发现了C4，在6个群体中发现了C3。C2和C4等位基因频率在这些少数民族群体中值得注意。C2等位基因频率较高（0.25 - 0.38），高于汉族（0.18 - 0.25）。在白族中，C2频率高达0.38。C4等位基因频率较低（低于0.01），这表明该等位基因可能在蒙古人种祖先群体中以低频率存在，并由于遗传漂变或其他因素在美洲印第安人中频率增加。