Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al Ahsa, Saudi Arabia.
PeerJ. 2022 Jul 8;10:e13665. doi: 10.7717/peerj.13665. eCollection 2022.
Iodine is a vital mineral of the human body that acts by maintaining the health of the thyroid gland. Research has shown that iodine-rich food allergy (., seafood allergy) is not caused by iodine itself; instead, it is caused by other proteins including tropomyosin and parvalbumin in shellfish and fish, respectively. Amiodarone is a commonly used antiarrhythmic agent containing a significant amount of iodine.
This study's objective was to assess pharmacists' knowledge, attitude, and practices toward the misconception of iodine allergy and the cross-reactivity with amiodarone.
In February 2020, a cross-sectional study was conducted by sending out an online survey to three pharmaceutical organizations (Saudi Pharmaceutical Society, Kuwait Pharmaceutical Association, and Oman Pharmaceutical Society). Additionally, an electronic questionnaire was administered to pharmacists attending the Dubai International Pharmaceuticals and Technologies Conference and Exhibition 2020 (DUPHAT). Chi-square or Fisher's exact test, when appropriate, were used to compare categorical variables. The statistical analyses were carried out using SPSS software.
Data were collected from 66 respondents. However, only 61 (92.4%) were included in the final analysis following the exclusion of incomplete responses. The mean age of participants was 35 ± 8.48 years. The majority of participants did not have the Board of Pharmacy Specialties Certification (54.1%). Moreover, (41%) of participants licensed as pharmacists with more than 10 years of initial pharmacy licensure. Forty-three (70.5%) of participants had the misconception that iodine allergy should be considered before amiodarone administration, 20/32 (62.5%) of whom considered iodine allergy alone thought that premedication with corticosteroids and/or antihistamines is necessary. Concerning iodine allergy and amiodarone use, there was no significant difference in knowledge between the pharmacists who have board certification and those who did not.
Pharmacists' misconception concerning iodine allergy and cross-reactivity with amiodarone was evident. Implementation of educational programs targeting pharmacists is necessary to correct these misconceptions.
碘是人体必需的矿物质，它通过维持甲状腺的健康来发挥作用。研究表明，富含碘的食物过敏（例如海鲜过敏）不是由碘本身引起的，而是由贝类和鱼类中的其他蛋白质引起的，分别为肌球蛋白和副肌球蛋白。胺碘酮是一种常用的抗心律失常药物，含有大量的碘。
本研究的目的是评估药剂师对碘过敏和与胺碘酮交叉反应的误解的知识、态度和实践。
2020 年 2 月，通过向三个制药组织（沙特制药协会、科威特制药协会和阿曼制药协会）发送在线调查，开展了一项横断面研究。此外，还向参加 2020 年迪拜国际药品技术会议和展览（DUPHAT）的药剂师发放了电子问卷。适当情况下使用卡方检验或 Fisher 精确检验比较分类变量。统计分析使用 SPSS 软件进行。
共收集了 66 名受访者的数据。然而，在排除不完整的回复后，只有 61 名（92.4%）被纳入最终分析。参与者的平均年龄为 35 ± 8.48 岁。大多数参与者没有药学专业委员会认证（54.1%）。此外，（41%）的参与者是拥有超过 10 年初始药学执照的药师。43（70.5%）的参与者存在碘过敏应在胺碘酮给药前考虑的误解，其中 20/32（62.5%）人认为单独考虑碘过敏时，需要预先使用皮质类固醇和/或抗组胺药。关于碘过敏和胺碘酮的使用，有委员会认证的药剂师和没有委员会认证的药剂师之间的知识没有显著差异。
药剂师对碘过敏和与胺碘酮交叉反应的误解很明显。有必要针对药剂师实施教育计划，以纠正这些误解。
