Department of Orthopedics, The First Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Int Wound J. 2023 Feb;20(2):261-268. doi: 10.1111/iwj.13869. Epub 2022 Jul 14.
We performed a meta-analysis to evaluate the effect of serologic malnutrition on postoperative wound infection problems after total joint arthroplasty. A systematic literature search up to April 2022, was performed and 446 501 subjects with total joint arthroplasty at the baseline of the studies; 200 433 of them were confirmed serologic malnutrition, and 246 068 were confirmed normal nutrition. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to assess the effect of serologic malnutrition on postoperative wound infection problems after total joint arthroplasty using the dichotomous method with a random or fixed-effect model. The serologic malnutrition subjects had a significantly higher wound disruption (OR, 1.97; 95% CI, 1.53-2.53, P < 0.001), higher superficial incisional surgical site infection (OR, 2.89; 95% CI, 1.67-5.01, P < 0.001), higher deep incisional surgical site infection (OR, 3.06; 95% CI, 2.36-3.96, P < 0.001), and higher organ space surgical site infection (OR, 3.15; 95% CI, 2.34-4.24, P < 0.001) in subjects after total joint arthroplasty compared with normal nutrition. The serologic malnutrition subjects had a significantly higher wound disruption, superficial incisional surgical site infection, deep incisional surgical site infection, and organ space surgical site infection in subjects after total joint arthroplasty compared with normal nutrition. The analysis of outcomes should be with caution because of the low number of studies in certain comparisons.
我们进行了一项荟萃分析，以评估血清营养不良对全关节置换术后伤口感染问题的影响。系统文献检索截至 2022 年 4 月，共纳入 446501 例基线研究中有全关节置换术的患者；其中 200433 例患者被确诊为血清营养不良，246068 例患者被确诊为正常营养。采用二项式方法，以随机或固定效应模型计算比值比（OR）和 95%置信区间（CI），评估血清营养不良对全关节置换术后伤口感染问题的影响。血清营养不良组的伤口裂开（OR，1.97；95%CI，1.53-2.53，P<0.001）、浅表切口手术部位感染（OR，2.89；95%CI，1.67-5.01，P<0.001）、深部切口手术部位感染（OR，3.06；95%CI，2.36-3.96，P<0.001）和器官间隙手术部位感染（OR，3.15；95%CI，2.34-4.24，P<0.001）的发生率明显高于正常营养组。血清营养不良组的伤口裂开、浅表切口手术部位感染、深部切口手术部位感染和器官间隙手术部位感染的发生率明显高于正常营养组。由于某些比较的研究数量较少，因此分析结果应谨慎对待。
