Gouveri Evanthia, Steiropoulos Paschalis, Papanas Nikolaos
Diabetes Centre Dr Tews, Hessen, Germany.
Department of Respiratory Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Int J Low Extrem Wounds. 2025 Jun;24(2):294-298. doi: 10.1177/15347346221113992. Epub 2022 Jul 14.
Both obstructive sleep apnoea syndrome (OSAS) and diabetes mellitus (DM) are common conditions that often coexist and share many similar risk factors. Diabetic foot is a common complication of DM, which may lead to lower-limb amputation. OSAS is considered a risk factor for type 2 DM (T2DM). There is also evidence that OSAS may be linked with the development, as well as the healing of diabetic foot. Multiple mechanisms triggered by sleep fragmentation and intermittent hypoxaemia in OSAS could contribute to the development of diabetic foot ulcers (DFUs). More interestingly, emerging evidence implies a favourable impact of continuous positive airway pressure (CPAP) treatment on DFU healing. Healing DFUs and minimising recurrence rates remains a challenge for health care professionals. In this context, management of OSAS might prove a useful therapeutic adjunct for DFUS. However, data is still limited and randomised controlled trials are needed to further explore this interesting potential.
阻塞性睡眠呼吸暂停综合征（OSAS）和糖尿病（DM）都是常见病症，常常并存且有许多相似的风险因素。糖尿病足是DM的常见并发症，可能导致下肢截肢。OSAS被认为是2型糖尿病（T2DM）的一个风险因素。也有证据表明，OSAS可能与糖尿病足的发生以及愈合有关。OSAS中由睡眠片段化和间歇性低氧血症引发的多种机制可能导致糖尿病足溃疡（DFU）的发生。更有趣的是，新出现的证据表明持续气道正压通气（CPAP）治疗对DFU愈合有积极影响。治愈DFU并将复发率降至最低对医护人员来说仍然是一项挑战。在这种情况下，OSAS的管理可能被证明是DFU的一种有用的治疗辅助手段。然而，数据仍然有限，需要进行随机对照试验来进一步探索这一有趣的可能性。
