State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Org Lett. 2022 Jul 22;24(28):5197-5202. doi: 10.1021/acs.orglett.2c02027. Epub 2022 Jul 14.
Herein, we describe a method to produce ()-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF. This synthetic method uses inexpensive and easy-to-handle TMSCF. It employs a commercially available CuCl catalyst to transform a broad range of carboxylic acids into versatile ()-trifluoromethyl enol esters with good regio- and stereoselectivity. This protocol allows the concise synthesis of highly functionalized ()-trifluoromethyl enol esters directly from carboxylic acids.
在此，我们描述了一种通过 TMSCF 对羧酸进行烯丙基化和三氟甲基化来制备 ()-三氟甲基烯醇酯的方法。这种合成方法使用廉价且易于处理的 TMSCF。它采用市售的 CuCl 催化剂，将广泛的羧酸转化为具有良好区域和立体选择性的多功能 ()-三氟甲基烯醇酯。该方案允许直接从羧酸简洁地合成高度官能化的 ()-三氟甲基烯醇酯。
