血小板与血红蛋白比值：预测急性肺栓塞严重程度和预后的新标志物。

Novel marker for predicting the severity and prognosis of acute pulmonary embolism: platelet-to-hemoglobin ratio.

机构信息

Department of Cardiology, Pursaklar State Hospital, Ankara, 06145, Turkey.

Department of Emergency Medicine, Pursaklar State Hospital, Ankara, 06145, Turkey.

出版信息

Biomark Med. 2022 Aug;16(12):915-924. doi: 10.2217/bmm-2022-0201. Epub 2022 Jul 14.

DOI:10.2217/bmm-2022-0201

PMID:35833861

Abstract

We investigated the ability of the platelet-to-hemoglobin ratio (PHR) to predict mortality and disease severity in patients with acute pulmonary embolism (APE). The severity of APE was classified as massive (high risk), submassive (intermediate risk) or nonmassive (low risk). PHR is defined as platelet count/hemoglobin count. PHR was significantly higher in patients with massive APE, and this elevation showed a gradual increase from the nonmassive group to the massive group (p < 0.001). In-hospital and 1-month mortality were higher in patients with high PHR values. PHR was an independent risk factor for the development of massive APE (odds ratio: 1.014; 95% CI: 1.011-1.017; p = 0.009). PHR values predicted massive APE and were an independent predictor of mortality in APE.

摘要

我们研究了血小板与血红蛋白比值（PHR）在急性肺栓塞（APE）患者中预测死亡率和疾病严重程度的能力。APE 的严重程度分为大块（高风险）、次大块（中风险）或非大块（低风险）。PHR 定义为血小板计数/血红蛋白计数。大块 APE 患者的 PHR 显著升高，这种升高从非大块组到大块组逐渐增加（p<0.001）。高 PHR 值患者的住院和 1 个月死亡率更高。PHR 是大块 APE 发展的独立危险因素（优势比：1.014；95%可信区间：1.011-1.017；p=0.009）。PHR 值预测大块 APE，是 APE 患者死亡率的独立预测因子。