Department of Entomology, National Taiwan University, Taipei City 106, Taiwan, China.
Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, United States.
J Agric Food Chem. 2022 Jul 27;70(29):8913-8919. doi: 10.1021/acs.jafc.2c03821. Epub 2022 Jul 14.
On average, it has taken approximately 10 years and $250 million to discover and develop one pesticide out of approximately 100 000 compounds. A successful pesticide researcher nowadays needs to be knowledgeable and skillful in multiple disciplines. As a result of the high costs and unique requirements, only a handful of companies in the world can afford to continue pesticide research and development (R/D) in the $70 billion pesticide market. Pesticide R/D is a high-risk yet high-reward business. In this perspective, pesticide R/D is briefly discussed and a case study is used to illustrate how spinosad was discovered and became a successful product, despite the many challenges facing pesticide R/D.
平均而言，从大约 10 万种化合物中发现和开发一种农药大约需要 10 年时间和 2.5 亿美元。如今，一位成功的农药研究人员需要在多个学科领域具备知识和技能。由于成本高昂和独特的要求，全世界只有少数几家公司能够负担得起在 700 亿美元的农药市场中继续进行农药研发（R/D）。农药 R/D 是一项高风险但高回报的业务。在这方面，简要讨论了农药 R/D，并通过案例研究说明了如何发现和开发出成功的产品——多杀菌素，尽管面临许多农药 R/D 所面临的挑战。
