Kahramanmaraş Sütçü İmam University, Faculty of Medicine.
Kardiologiia. 2022 Jun 30;62(6):45-50. doi: 10.18087/cardio.2022.6.n2049.
Aim Cardiac autonomic dysfunction is encountered in approximately 25 % of patients with metabolic syndrome (MetS). 24 hr Holter-ECG based heart rate variability (HRV) and heart rate turbulence (HRT) parameters are used to evaluate cardiac autonomic function. We aimed to investigate the relationship between a novel insulin resistance marker, triglyceride glucose (TyG) index and cardiac autonomic dysfunction in patients with MetS.Material and methods We examined a total of 400 non-diabetic subjects, 136 with MetS and 264 without MetS. All underwent TyG index calculations, and 24 hr Holter-ECG recordings for the measurement of HRV and HRT parameters.Results HRV and HRT parameters were lower or higher in patients with MetS than in subjects without MetS, indicating cardiac autonomic dysfunction. We observed significant correlations between TyG index and measures of cardiac autonomic function. Multiple linear regression analysis showed that the TyG index was an independent predictor of almost all HRV and HRT parameters.Conclusion This study demonstrates the independent relationship between cardiac autonomic dysfunction and the TyG index, a novel marker of insulin resistance in non-diabetic patients with MetS.
目的 代谢综合征（MetS）患者中约有 25%存在心脏自主神经功能障碍。24 小时动态心电图心率变异性（HRV）和心率震荡（HRT）参数用于评估心脏自主神经功能。我们旨在研究一种新的胰岛素抵抗标志物——甘油三酯葡萄糖（TyG）指数与 MetS 患者心脏自主神经功能障碍之间的关系。
材料与方法 我们共检查了 400 名非糖尿病患者，其中 136 名患有 MetS，264 名无 MetS。所有患者均进行了 TyG 指数计算，并进行了 24 小时动态心电图记录，以测量 HRV 和 HRT 参数。
结果 MetS 患者的 HRV 和 HRT 参数低于或高于无 MetS 患者，表明存在心脏自主神经功能障碍。我们观察到 TyG 指数与心脏自主神经功能测量值之间存在显著相关性。多元线性回归分析表明，TyG 指数是几乎所有 HRV 和 HRT 参数的独立预测因子。
结论 本研究表明，在非糖尿病 MetS 患者中，心脏自主神经功能障碍与 TyG 指数（一种新的胰岛素抵抗标志物）之间存在独立关系。
