三酰甘油-葡萄糖（TyG）指数在成人代谢综合征筛查中的准确性：系统评价和荟萃分析。

The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: A systematic review and meta-analysis.

机构信息

Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran, Iran.

Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Nutr Metab Cardiovasc Dis. 2022 Dec;32(12):2677-2688. doi: 10.1016/j.numecd.2022.07.024. Epub 2022 Sep 2.

DOI:10.1016/j.numecd.2022.07.024

PMID:36336547

Abstract

AIMS

To investigate the relationship between the triglyceride-glucose (TyG) index, a novel surrogate index of insulin resistance (IR), and metabolic syndrome (MetS) in a systematic review and meta-analysis.

DATA SYNTHESIS

Studies that report the TyG index in adult subjects with and without MetS were included. Thirteen observational articles were included in this study, with a total of 49,325 participants. Two different categories of meta-analyses were performed. First, the means of the TyG index were compared in participants with and without MetS. The pooled mean difference (MD) of the TyG index between groups was 0.83 units (CI 95: 0.74-0.92, I2 = 98, P-value < 0.001), and the subgroup analyses showed MD significantly differed based on the MetS diagnostic criteria. The pooled MD were 0.80 units (CI 95: 0.70-0.91, I2 = %88, P-value < 0.001) and 0.82 units (CI 95: 0.79-0.86, I2 = %0, P-value > 0.767) for studies reported data for males and females individual, respectively. Second bivariate diagnostic test accuracy (DTA) meta-analysis was performed and determined that the TyG index's pooled sensitivity and specificity for screening of MetS were 80% (CI95: 75%-84%, I2 = 87%, P-value < 0.001) and 81% (CI95: 77%-84%, I2 = 90.45%, P-value < 0.001), respectively. Summary receiver-operating characteristics (sROC) curves were also plotted with the area under the sROC curve of 0.87 (CI 95: 0.84-0.90).

CONCLUSIONS

The TyG index is a sensitive and specific index for MetS and may be valuable for MetS screening.

PROSPERO

CRD42022316209.

摘要

目的

通过系统评价和荟萃分析，研究三酰甘油-葡萄糖（TyG）指数作为一种新的胰岛素抵抗（IR）替代指标与代谢综合征（MetS）之间的关系。

数据合成

纳入了报告成人受试者中伴有和不伴有 MetS 的 TyG 指数的研究。本研究共纳入了 13 项观察性文章，总计 49325 名参与者。进行了两种不同类别的荟萃分析。首先，比较了伴有和不伴有 MetS 的参与者的 TyG 指数平均值。两组之间 TyG 指数的合并平均差（MD）为 0.83 个单位（95%CI：0.74-0.92，I2=98，P 值<0.001），亚组分析显示，根据 MetS 诊断标准，MD 差异显著。对于分别报告男性和女性个体数据的研究，MD 分别为 0.80 个单位（95%CI：0.70-0.91，I2=88%，P 值<0.001）和 0.82 个单位（95%CI：0.79-0.86，I2=0%，P 值>0.767）。其次，进行了二元诊断试验准确性（DTA）荟萃分析，确定 TyG 指数筛查 MetS 的合并敏感性和特异性分别为 80%（95%CI：75%-84%，I2=87%，P 值<0.001）和 81%（95%CI：77%-84%，I2=90.45%，P 值<0.001）。还绘制了综合受试者工作特征（sROC）曲线，sROC 曲线下面积为 0.87（95%CI：0.84-0.90）。