Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, United States of America.
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States of America.
PLoS One. 2022 Jul 14;17(7):e0266664. doi: 10.1371/journal.pone.0266664. eCollection 2022.
There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.
目前尚无批准的药物可用于治疗妊娠期寨卡病毒（ZIKV）感染。人免疫球蛋白类药物如 VARIZIG 和 WinRho 已获得 FDA 批准，可用于治疗妊娠期疾病，如水痘带状疱疹病毒感染和 Rh 不相容。我们在感染寨卡病毒一天后，对感染寨卡病毒的妊娠恒河猴给予寨卡病毒特异性人免疫球蛋白进行治疗。所有动物在治疗后均控制了寨卡病毒血症，并在血液中产生了高水平的抗寨卡病毒抗体。在接受治疗的动物中未发现胎儿或婴儿不良结局，但接受安慰剂对照治疗的动物也没有先天性寨卡综合征（CZS）相关迹象。人免疫球蛋白可能是妊娠期寨卡病毒感染的一种可行的预防和治疗选择，但需要更多的研究来全面评估该治疗方法预防 CZS 的效果。
