Department of Cardiac Surgery, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, China.
Aging (Albany NY). 2020 Jun 4;12(11):10290-10299. doi: 10.18632/aging.103248.
The etiology of schizophrenia is still unknown, and the gene has been shown to be associated with SCZ. Previous studies have shown that patients with schizophrenia exhibit sex differences in symptoms and cognitive function. However, no study has been conducted to investigate the sex difference in the association between C677T polymorphism and symptoms and cognitive impairment in Chinese patients with schizophrenia. The C677T polymorphism was genotyped in 957 patients with schizophrenia and 576 controls. Patients were also rated on the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The results showed that there were significant differences in C677T genotype and allele distributions between male patients and male controls (both p<0.05), while there was no significant difference between female patients and female controls (both p>0.05). Further analysis showed that there were significant sex differences in the association between C677T genotype and negative symptoms, immediate memory or attention index score in schizophrenia (p<0.05). This study suggests that the complex interactive effect between C677T polymorphism and sex plays an important role in some clinical characteristics of patients with schizophrenia.
精神分裂症的病因仍不清楚，基因已被证明与 SCZ 有关。先前的研究表明，精神分裂症患者在症状和认知功能方面存在性别差异。然而，尚未有研究调查中国精神分裂症患者中 C677T 多态性与症状和认知障碍之间的关联的性别差异。对 957 名精神分裂症患者和 576 名对照进行了 C677T 多态性基因分型。患者还进行了阳性和阴性综合征量表（PANSS）和重复神经心理状态评估电池（RBANS）的评分。结果表明，男性患者和男性对照组之间 C677T 基因型和等位基因分布存在显著差异（均 p<0.05），而女性患者和女性对照组之间无显著差异（均 p>0.05）。进一步分析表明，C677T 基因型与精神分裂症阴性症状、即刻记忆或注意力指数评分之间的关联存在显著的性别差异（p<0.05）。这项研究表明，C677T 多态性与性别的复杂交互作用在精神分裂症患者的某些临床特征中起着重要作用。
