Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki GR-54124, Greece.
Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki GR-54124, Greece.
J Inorg Biochem. 2022 Oct;235:111923. doi: 10.1016/j.jinorgbio.2022.111923. Epub 2022 Jul 8.
A series of Mn(II) complexes of 5-nitro-salicyladehyde or substituted 2-hydroxy-phenones (HL) were synthesized in the absence or presence of a N,N'-donor co-ligand such as 2,2'-bipyridine, 1,10-phenanthroline, or 2,2'-bipyridylamine. The resultant coordination compounds were formulated as [Mn(L)(CHOH)] (1-3) and [Mn(L)(N,N'-donor)] (4-14), respectively, and characterized by diverse techniques. The crystal structures of three complexes were determined by single-crystal X-ray crystallography. Diverse techniques were employed to study the interaction of the complexes with calf-thymus DNA and showed intercalation as the most possible mode of their tight interaction. The affinity of the complexes for bovine serum albumin was investigated by fluorescence emission spectroscopy in order to calculate the binding constants which suggested a tight and reversible binding.
一系列的 Mn(II) 配合物的 5-硝基水杨醛或取代 2-羟基苯酮 (HL) 是在不存在或存在 N,N'-双齿配体如 2,2'-联吡啶、1,10-菲咯啉或 2,2'-联吡啶胺。所得配合物被表述为 [Mn(L)(CHOH)] (1-3) 和 [Mn(L)(N,N'-配体)] (4-14)，分别，并通过多种技术进行了表征。三个配合物的晶体结构通过单晶 X 射线晶体学确定。多种技术被用于研究配合物与小牛胸腺 DNA 的相互作用，并显示出它们紧密相互作用的最可能模式是嵌入。配合物与牛血清白蛋白的亲和力通过荧光发射光谱法进行了研究，以便计算结合常数，这表明了紧密和可逆的结合。
