Rheumatology Unit, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
Internal Medicine A, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
Microvasc Res. 2022 Sep;143:104406. doi: 10.1016/j.mvr.2022.104406. Epub 2022 Jul 11.
Nailfold video capillaroscopy (NVC) enables us a direct view of the microvasculature. Only several capillaroscopy studies in adult patients with vasculitis have been reported.
To characterize NVC changes in vasculitis.
Vasculitis patients and healthy controls were evaluated by NVC. NVC changes associated with vasculitis were assessed retrospectively in a cohort of 100 patients with Raynaud's phenomenon (RP).
17 patients with active vasculitis and 8 patients with vasculitis in remission were compared to 25 age and sex-matched healthy controls. Active vasculitis patients demonstrated higher rates of neoangiogenesis and capillary loss in comparison to other groups. Two novel NVC abnormalities were observed in patients with vasculitis: "Rolling" (slow capillary flow) and "peri-capillary stippling" (PCS), small deposits that may represent capillary leak. PCS was observed exclusively in 5 of 17 patients with active vasculitis. Retrospectively, we were able to detect PCS also in 14 % of 100 patients that were evaluated for RP, of whom 64 % were diagnosed with scleroderma or a related disorder.
Patients with active vasculitis demonstrate frequent capillary abnormalities. Although these abnormalities are non-specific, we suggest that their combination may aid the diagnosis of vasculitis. Future studies are needed to validate our findings.
甲襞微循环视频检查（NVC）使我们能够直接观察微血管。仅有少数关于成人血管炎患者的毛细血管检查研究报告。
描述血管炎的 NVC 变化。
通过 NVC 评估血管炎患者和健康对照者。回顾性评估了 100 例雷诺现象（RP）患者队列中与血管炎相关的 NVC 变化。
将 17 例活动期血管炎患者和 8 例缓解期血管炎患者与 25 例年龄和性别匹配的健康对照者进行比较。与其他组相比，活动期血管炎患者的新生血管形成和毛细血管丢失率更高。在血管炎患者中观察到两种新的 NVC 异常：“滚动”（毛细血管缓慢流动）和“毛细血管周围点状”（PCS），这可能是毛细血管渗漏的小沉积物。在 17 例活动期血管炎患者中观察到了 PCS，其中 5 例患者观察到了 PCS。回顾性分析发现，在 100 例接受 RP 评估的患者中，有 14%的患者也存在 PCS，其中 64%的患者被诊断为硬皮病或相关疾病。
活动期血管炎患者表现出频繁的毛细血管异常。尽管这些异常是非特异性的，但我们认为它们的组合可能有助于血管炎的诊断。需要进一步的研究来验证我们的发现。
