Cui Qianwei, Zhu Xu, Guan Gongchang, Hui Rutai, Zhu Ling, Wang Junkui
Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, China.
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu, 210000, China.
Chemosphere. 2022 Nov;307(Pt 1):135669. doi: 10.1016/j.chemosphere.2022.135669. Epub 2022 Jul 11.
The purpose of this study was to examine the relationship between N,N-diethyl-m-toluamide (DEET) exposure and obesity-related outcomes in the general adult population using the data from the National Health and Nutrition Examination Survey (NHANES).
This cross-sectional study examined the data from the NHANES from 2007 to 2016 and totally evaluated 8,770 individuals. DEET's primary oxidative metabolite, 3-(diethylcarbamoyl) benzoic acid (DCBA), is a sensitive and specific indicator of DEET exposure. DCBA was divided into three groups based on the interquartile range. Body mass index (BMI) and waist circumference (WC) were used to define obesity and abdominal obesity, respectively. The association among DCBA and obesity-related outcomes was evaluated using a multivariable linear and logistic regression model.
Overall, median age of participants was 46.0 (IQR 31.0, 59.0) years, with 4295 (49.2%) men, while median BMI and WC were 27.8 (24.0, 32.0) and 29.6 (86.6, 108.1) kg/m, respectively. Approximately 3,251 (35.9%) cases of obesity and 4,778 cases (54.4%) of abdominal obesity were observed. In multivariable-adjusted linear regression models, as the tertiles of DCBA increased, BMI and WC monotonically increased regardless of the adjustments (all p for trend <0.01). By referring the lowest tertile of DCBA, the highest tertile was associated with a higher BMI (β = 0.83, 95% confidence intervals [CI] [0.45, 1.21]; p < 0.001) and WC (β = 1.59, 95% CI [0.59, 2.60]; p = 0.002). The multivariate odds ratios (95% CI) for obesity increased monotonically as 1.18 (0.97-1.44) and 1.36 (1.15-1.61) (p for trend 0.001). Similar associations between DCBA and the prevalence of abdominal obesity were observed across increasing DCBA tertiles compared with the reference tertile (OR = 1.22, 95% CI [1.02, 1.44]; OR = 1.28, 95% CI [1.08-1.54]; p for trend = 0.002).
These findings suggested that higher DCBA concentrations are positively associated with the prevalence of obesity and abdominal obesity in the general adult population.
本研究旨在利用美国国家健康与营养检查调查（NHANES）的数据，探讨普通成年人群中N，N - 二乙基 - 间甲苯甲酰胺（避蚊胺，DEET）暴露与肥胖相关结局之间的关系。
这项横断面研究分析了2007年至2016年NHANES的数据，共评估了8770名个体。DEET的主要氧化代谢产物3 - （二乙氨基甲酰基）苯甲酸（DCBA）是DEET暴露的敏感且特异的指标。根据四分位数间距将DCBA分为三组。体重指数（BMI）和腰围（WC）分别用于定义肥胖和腹型肥胖。使用多变量线性和逻辑回归模型评估DCBA与肥胖相关结局之间的关联。
总体而言，参与者的中位年龄为46.0（四分位间距31.0，59.0）岁，男性有4295名（49.2%），而BMI和WC的中位数分别为27.8（24.0，32.0）和29.6（86.6，108.1）kg/m。观察到约3251例（35.9%）肥胖病例和4778例（54.4%）腹型肥胖病例。在多变量调整线性回归模型中，随着DCBA三分位数的增加，无论如何调整，BMI和WC均单调增加（所有趋势p<0.01）。与DCBA最低三分位数相比，最高三分位数与更高的BMI（β = 0.83，95%置信区间[CI][0.45，1.21]；p<0.001）和WC（β = 1.59，95%CI[0.59，2.60]；p = 0.002）相关。肥胖的多变量比值比（95%CI）随着1.18（0.97 - 1.44）和1.36（1.15 - 1.61）单调增加（趋势p = 0.001）。与参考三分位数相比，在DCBA三分位数增加的情况下，观察到DCBA与腹型肥胖患病率之间存在类似的关联（OR = 1.22，95%CI[1.02，1.44]；OR = 1.28，95%CI[1.08 - 1.54]；趋势p = 0.002）。
这些发现表明，较高的DCBA浓度与普通成年人群中肥胖和腹型肥胖的患病率呈正相关。
