rs9939609 FTO和rs17782313 MC4R的基因型频率及哈迪-温伯格平衡：对儿童和青少年超重及肥胖统计关联的影响（参考“儿童和青少年肥胖中rs9939609 FTO和rs17782313 MC4R基因的多态性：一项系统综述”） - Suppr

Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313 MC4R: Implications for statistical associations to overweight and obesity in children and adolescents (re. "Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: a systematic review").

作者信息

Flores Sergio V, Roco-Videla Angel, Silva-González Omar

机构信息

Dirección de Desarrollo y Postgrado. Universidad Autónoma de Chile, Santiago, Chile; Laboratorio de Genética y Evolución, GEVOL.

Facultad de Ciencias de Salud, programa de Magister en Ciencias Químico-Biológicas. Universidad Bernardo O'Higgins, Santiago, Chile; Facultad de Ingeniería, Departamento de Ingeniería Civil, Universidad Católica de la Santísima Concepción, Concepción-Chile.

出版信息

Nutrition. 2022 Nov-Dec;103-104:111745. doi: 10.1016/j.nut.2022.111745. Epub 2022 May 21.

DOI:10.1016/j.nut.2022.111745

PMID:35835628

Abstract

摘要

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Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313 MC4R: Implications for statistical associations to overweight and obesity in children and adolescents (re. "Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: a systematic review").rs9939609 FTO和rs17782313 MC4R的基因型频率及哈迪-温伯格平衡：对儿童和青少年超重及肥胖统计关联的影响（参考“儿童和青少年肥胖中rs9939609 FTO和rs17782313 MC4R基因的多态性：一项系统综述”）

Nutrition. 2022 Nov-Dec;103-104:111745. doi: 10.1016/j.nut.2022.111745. Epub 2022 May 21.

Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: A systematic review.FTO 基因 rs9939609 多态性和 MC4R 基因 rs17782313 多态性与儿童和青少年肥胖的关系：系统评价。

Nutrition. 2021 Nov-Dec;91-92:111474. doi: 10.1016/j.nut.2021.111474. Epub 2021 Aug 31.

Common polymorphisms in MC4R and FTO genes are associated with BMI and metabolic indicators in Mexican children: Differences by sex and genetic ancestry.MC4R和FTO基因的常见多态性与墨西哥儿童的体重指数和代谢指标相关：性别和遗传血统的差异

Gene. 2020 Sep 5;754:144840. doi: 10.1016/j.gene.2020.144840. Epub 2020 Jun 4.

Combined effect of FTO and MC4R gene polymorphisms on obesity in children and adolescents in Northwest China: a case-control study.FTO和MC4R基因多态性对中国西北儿童和青少年肥胖的联合作用：一项病例对照研究

Asia Pac J Clin Nutr. 2019;28(1):177-182. doi: 10.6133/apjcn.201903_28(1).0023.

Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity.评价 FTO(rs9939609)和 MC4R(rs17782313)基因多态性在 1 型糖尿病中的作用及其与肥胖的关系。

J Pediatr Endocrinol Metab. 2024 Jan 11;37(2):110-122. doi: 10.1515/jpem-2023-0372. Print 2024 Feb 26.

Evidence from a meta-analysis for association of MC4R rs17782313 and FTO rs9939609 polymorphisms with susceptibility to obesity in children.荟萃分析表明 MC4R rs17782313 和 FTO rs9939609 多态性与儿童肥胖易感性相关。

Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102234. doi: 10.1016/j.dsx.2021.102234. Epub 2021 Jul 30.

FTO and MC4R polymorphisms, and selected pre-, peri- and postnatal factors as determinants of body mass index and fatness in children: a thorough analysis of the associations.FTO 和 MC4R 多态性，以及选定的产前、围产期和产后因素作为儿童体重指数和肥胖的决定因素：对关联的全面分析。

J Physiol Anthropol. 2023 Dec 8;42(1):29. doi: 10.1186/s40101-023-00344-1.

Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.LEPR、FTO、MC4R 和 PPARG-2 多态性与学龄儿童肥胖特征和代谢表型的关联。

Endocrine. 2018 Jun;60(3):466-478. doi: 10.1007/s12020-018-1587-3. Epub 2018 Apr 20.

The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women.非裔美国女性中肥胖相关的多态性 FTO rs9939609 和 MC4R rs17782313 与子宫内膜癌风险的关系。

PLoS One. 2011 Feb 8;6(2):e16756. doi: 10.1371/journal.pone.0016756.

Could Hardy-Weinberg disequilibrium bring conclusive results in studies that link genetic markers and risk of disease development? Comment on "Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313MC4R: implications for statistical associations to overweight and obesity in children and adolescents".哈迪-温伯格不平衡能否在将基因标记与疾病发生风险联系起来的研究中带来确定性结果？评《rs9939609 FTO和rs17782313 MC4R的基因型频率与哈迪-温伯格平衡：对儿童和青少年超重及肥胖统计关联的影响》

Nutrition. 2022 Nov-Dec;103-104:111792. doi: 10.1016/j.nut.2022.111792. Epub 2022 Jul 12.

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