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Could Hardy-Weinberg disequilibrium bring conclusive results in studies that link genetic markers and risk of disease development? Comment on "Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313MC4R: implications for statistical associations to overweight and obesity in children and adolescents".

作者信息

Resende Cristina Maria Mendes, Muniz Maria Tereza Cartaxo

机构信息

Graduate Program in Hebiatria, University of Pernambuco, Recife, Brazil.

Graduate Program in Molecular and Cell Biology, University of Pernambuco, Recife, Brazil.

出版信息

Nutrition. 2022 Nov-Dec;103-104:111792. doi: 10.1016/j.nut.2022.111792. Epub 2022 Jul 12.

DOI:10.1016/j.nut.2022.111792
PMID:35989140
Abstract
摘要

相似文献

1
Could Hardy-Weinberg disequilibrium bring conclusive results in studies that link genetic markers and risk of disease development? Comment on "Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313MC4R: implications for statistical associations to overweight and obesity in children and adolescents".哈迪-温伯格不平衡能否在将基因标记与疾病发生风险联系起来的研究中带来确定性结果？评《rs9939609 FTO和rs17782313 MC4R的基因型频率与哈迪-温伯格平衡：对儿童和青少年超重及肥胖统计关联的影响》
Nutrition. 2022 Nov-Dec;103-104:111792. doi: 10.1016/j.nut.2022.111792. Epub 2022 Jul 12.
2
Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313 MC4R: Implications for statistical associations to overweight and obesity in children and adolescents (re. "Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: a systematic review").rs9939609 FTO和rs17782313 MC4R的基因型频率及哈迪-温伯格平衡：对儿童和青少年超重及肥胖统计关联的影响（参考“儿童和青少年肥胖中rs9939609 FTO和rs17782313 MC4R基因的多态性：一项系统综述”）
Nutrition. 2022 Nov-Dec;103-104:111745. doi: 10.1016/j.nut.2022.111745. Epub 2022 May 21.
3
FTO genotype and weight status among preadolescents: Assessing the mediating effects of obesogenic appetitive traits.FTO 基因型与青少年前期体重状况：评估肥胖相关食欲特征的中介效应。
Appetite. 2017 Oct 1;117:321-329. doi: 10.1016/j.appet.2017.07.009. Epub 2017 Jul 13.
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Genetic Variants in the Fat Mass and Obesity-Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta-Analysis.脂肪量和肥胖相关基因中的遗传变异与儿童和青少年肥胖/超重风险的关系：系统评价和荟萃分析。
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5
Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.FTO 基因的遗传变异：rs1421085 T>C、rs8057044 G>A、rs9939609 T>A 以及拷贝数变异（CNV）在肥胖/超重和体重正常的墨西哥梅萨印第安学龄儿童中的分布。
Am J Hum Biol. 2019 Jan;31(1):e23192. doi: 10.1002/ajhb.23192. Epub 2018 Dec 10.
6
Common polymorphisms in MC4R and FTO genes are associated with BMI and metabolic indicators in Mexican children: Differences by sex and genetic ancestry.MC4R和FTO基因的常见多态性与墨西哥儿童的体重指数和代谢指标相关：性别和遗传血统的差异
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Eur J Pediatr. 2021 Nov;180(11):3325-3333. doi: 10.1007/s00431-021-04120-0. Epub 2021 May 21.
8
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J Pediatr (Rio J). 2016 Sep-Oct;92(5):493-8. doi: 10.1016/j.jped.2015.11.005. Epub 2016 May 4.
9
Polymorphisms on rs9939609 FTO and rs17782313 MC4R genes in children and adolescent obesity: A systematic review.FTO 基因 rs9939609 多态性和 MC4R 基因 rs17782313 多态性与儿童和青少年肥胖的关系：系统评价。
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10
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Asia Pac J Clin Nutr. 2019;28(1):177-182. doi: 10.6133/apjcn.201903_28(1).0023.